HAART in treatment-experienced patients in the 21st century: the audacity of hope
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journal
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January 2009 |
Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naive Individuals
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journal
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January 2009 |
Thirty Years of HIV and AIDS: Future Challenges and Opportunities
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journal
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June 2011 |
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
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journal
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August 2011 |
Improvements in antiretroviral therapy outcomes over calendar time
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journal
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January 2009 |
Long-Term Effectiveness of Highly Active Antiretroviral Therapy on the Survival of Children and Adolescents with HIV Infection: A 10-Year Follow-Up Study
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journal
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February 2008 |
Emergence of Drug Resistance in HIV Type 1–Infected Patients after Receipt of First‐Line Highly Active Antiretroviral Therapy: A Systematic Review of Clinical Trials
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journal
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September 2008 |
Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV
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journal
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January 2012 |
Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors
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journal
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September 2010 |
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV
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journal
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December 2007 |
Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance
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journal
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September 2006 |
Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope against Drug-Resistant HIV
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book
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January 2010 |
Harnessing Nature’s Insight: Design of Aspartyl Protease Inhibitors from Treatment of Drug-Resistant HIV to Alzheimer’s Disease †
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journal
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April 2009 |
Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1–P2 ligands
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journal
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January 2014 |
Structure-Based Design: Synthesis and Biological Evaluation of a Series of Novel Cycloamide-Derived HIV-1 Protease Inhibitors
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journal
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May 2005 |
Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants
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journal
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December 2007 |
Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation
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journal
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February 2008 |
Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P 2 - P 3 -Ligands
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journal
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May 2007 |
Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase
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journal
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January 2004 |
Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P 2 Ligands: Structure−Activity Studies and Biological Evaluation
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journal
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January 2011 |
Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance
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journal
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August 2006 |
Transition-metal-catalyzed asymmetric organic synthesis via polymer-attached optically active phosphine ligands. 5. Preparation of amino acids in high optical yield via catalytic hydrogenation
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journal
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July 1981 |
Calcium Borohydride: A Reagent for Facile Conversion of Carboxylic Esters to Alcohols and Aldehydes
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journal
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June 1995 |
A simple, continuous fluorometric assay for HIV protease
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journal
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December 1990 |
Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro
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journal
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September 2003 |
High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains
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journal
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April 2004 |
Structural implications of drug-resistant mutants of HIV-1 protease: High-resolution crystal structures of the mutant protease/substrate analogue complexes
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journal
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January 2001 |
Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies
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journal
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September 2008 |
MOLREP an Automated Program for Molecular Replacement
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journal
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December 1997 |
Overview of the CCP 4 suite and current developments
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journal
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March 2011 |
A short history of SHELX
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journal
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December 2007 |
PRODRG : a tool for high-throughput crystallography of protein–ligand complexes
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journal
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July 2004 |