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Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs

Patent ·
OSTI ID:1223701
; ; ; ; ; ; ; ; ; ;

This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.

Research Organization:
The Scripps Research Institute, La Jolla, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-00ER45812
Assignee:
The Scripps Research Institute (La Jolla, CA)
Patent Number(s):
9,163,271
Application Number:
13/475,792
OSTI ID:
1223701
Country of Publication:
United States
Language:
English

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