L-phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins
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patent
|
December 1994 |
Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
|
patent
|
March 2004 |
Glycoprotein synthesis
|
patent
|
August 2005 |
In vivo incorporation of unnatural amino acids
|
patent
|
May 2006 |
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
|
patent
|
August 2006 |
Glycoprotein synthesis
|
patent
|
October 2006 |
Glycoprotein synthesis
|
patent
|
February 2007 |
Glycoprotein synthesis
|
patent
|
April 2007 |
Glycoprotein synthesis
|
patent
|
May 2007 |
Glycoprotein synthesis
|
patent
|
July 2007 |
Glycoprotein synthesis
|
patent
|
August 2007 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
|
patent
|
April 2008 |
In vivo incorporation of unnatural amino acids
|
patent
|
May 2008 |
In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
|
patent
|
May 2008 |
Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
|
patent
|
July 2008 |
Site specific incorporation of keto amino acids into proteins
|
patent
|
October 2008 |
Site-specific incorporation of redox active amino acids into proteins
|
patent
|
February 2009 |
Site specific incorporation of keto amino acids into proteins
|
patent
|
April 2009 |
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
patent
|
May 2009 |
Glycoprotein synthesis
|
patent
|
July 2009 |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
patent
|
August 2009 |
Expanding the eukaryotic genetic code
|
patent
|
October 2009 |
Expanding the eukaryotic genetic code
|
patent
|
November 2009 |
Expanding the eukaryotic genetic code
|
patent
|
December 2009 |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
patent
|
December 2009 |
In vivo incorporation of unnatural amino acids
|
patent
|
December 2009 |
Protein arrays
|
patent
|
January 2010 |
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
|
patent
|
May 2010 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
|
patent
|
May 2010 |
In vivo incorporation of alkynyl amino acids into proteins in eubacteria
|
patent
|
May 2010 |
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
|
patent
|
June 2010 |
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
|
patent
|
September 2010 |
Expanding the eukaryotic genetic code
|
patent
|
September 2010 |
Genetically encoded fluorescent coumarin amino acids
|
patent
|
October 2010 |
In vivo incorporation of alkynyl amino acids into proteins in eubacteria
|
patent
|
November 2010 |
Glycoprotein synthesis
|
patent
|
November 2010 |
Glycoprotein synthesis
|
patent
|
November 2010 |
|
patent-application
|
October 2004 |
Unnatural reactive amino acid genetic code additions
|
patent-application
|
December 2004 |
Expanding the eukaryotic genetic code
|
patent-application
|
January 2005 |
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
|
patent-application
|
June 2005 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
|
patent-application
|
September 2005 |
Site-specific incorporation of redox active amino acids into proteins
|
patent-application
|
October 2005 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
November 2005 |
Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
|
patent-application
|
December 2005 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
|
patent-application
|
March 2006 |
In vivo incorporation of alkynyl amino acids into proteins in eubacteria
|
patent-application
|
April 2006 |
Site-specific labeling of proteins for NMR studies
|
patent-application
|
May 2006 |
In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
|
patent-application
|
May 2006 |
Adding photoregulated amino acids to the genetic code
|
patent-application
|
June 2006 |
Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
patent-application
|
July 2006 |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
patent-application
|
August 2006 |
Unnatural reactive amino acid genetic code additions
|
patent-application
|
November 2006 |
Site-specific incorporation of redox active amino acids into proteins
|
patent-application
|
January 2007 |
Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
patent-application
|
January 2007 |
Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
patent-application
|
February 2007 |
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
|
patent-application
|
May 2007 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
May 2007 |
Expanding the eukaryotic genetic code
|
patent-application
|
July 2007 |
Expanding the eukaryotic genetic code
|
patent-application
|
July 2007 |
Glycoprotein synthesis
|
patent-application
|
July 2007 |
Selective posttranslational modification of phage-displayed polypeptides
|
patent-application
|
August 2007 |
Glycoprotein synthesis
|
patent-application
|
August 2007 |
Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
|
patent-application
|
October 2007 |
Systems for the expression of orthogonal translation components in eubacterial host cells
|
patent-application
|
December 2007 |
Genetically encoded fluorescent coumarin amino acids
|
patent-application
|
February 2008 |
In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria
|
patent-application
|
March 2008 |
Genetically programmed expression of selectively sulfated proteins in eubacteria
|
patent-application
|
May 2008 |
Genetic incorporation of unnatural amino acids into proteins in mammalian cells
|
patent-application
|
July 2008 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
July 2008 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
July 2008 |
Site-Specific Labeling of Proteins for Nmr Studies
|
patent-application
|
July 2008 |
Expanding the eukaryotic genetic code
|
patent-application
|
July 2008 |
Glycoprotein synthesis
|
patent-application
|
September 2008 |
In Vivo Incorporation of Alkynyl Amino Acids into Proteins in Eubacteria
|
patent-application
|
September 2008 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
September 2008 |
Site specific incorporation of keto amino acids into proteins
|
patent-application
|
September 2008 |
Expanding the eukaryotic genetic code
|
patent-application
|
September 2008 |
Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids
|
patent-application
|
September 2008 |
In vivo site-sepecific incorporation of N-acetyl-galactosamine amino acids in eubacteria
|
patent-application
|
October 2008 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
October 2008 |
Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
|
patent-application
|
February 2009 |
In vivo incorporation of unnatural amino acids
|
patent-application
|
March 2009 |
Site-specific labeling of proteins for NMR studies
|
patent-application
|
March 2009 |
Selective Posttranslational Modification of Phage-Displayed Polypeptides
|
patent-application
|
May 2009 |
Genetically Encoded Boronate Amino Acid
|
patent-application
|
June 2009 |
Directed evolution using proteins comprising unnatural amino acids
|
patent-application
|
June 2009 |
Systems for the Expression of Orthogonal Translation Components Eubacterial Host Cells
|
patent-application
|
July 2009 |
Adding photoregulated amino acids to the genetic code
|
patent-application
|
July 2009 |
In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
|
patent-application
|
August 2009 |
Genetic Incorporation of 3-Aminotyrosine Into Reductases
|
patent-application
|
August 2009 |
Genetically Programmed Expression of Proteins
|
patent-application
|
August 2009 |
Site specific incorporation of keto amino acids into proteins
|
patent-application
|
August 2009 |
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
|
patent-application
|
September 2009 |
Breaking immunological toterance with a genetically encoded unnatural amino acid
|
patent-application
|
October 2009 |
Genetically programmed expression of selectively sulfated proteins in eubacteria
|
patent-application
|
November 2009 |
Genetically encoded coumarin amino acids
|
patent-application
|
December 2009 |
Site-specific incorporation of redox active amino acids into proteins
|
patent-application
|
December 2009 |
Glycoprotein synthesis
|
patent-application
|
January 2010 |
Genetic incorporation of unnatural amino acids into proteins in mammalian cells
|
patent-application
|
January 2010 |
Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
|
patent-application
|
November 2010 |
Illicit Transport: The Oligopeptide Permease
|
journal
|
February 1973 |
Exploring the Limits of Codon and Anticodon Size
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journal
|
February 2002 |
Glutamine analogues as potential antimalarials
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journal
|
March 1991 |
Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide
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journal
|
September 1989 |
Synthesis of novel α-amino-acids and derivatives using radical chemistry: synthesis of L- and D-α-amino-adipic acids, L-α
|
journal
|
January 1987 |
Bio–incorporation of telluromethionine into buried residues of dihydrofolate reductase
|
journal
|
May 1994 |
Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution: Interaction of the enzyme with the tyrosyl adenylate intermediate
|
journal
|
July 1989 |
New Photolabeling and Crosslinking Methods
|
journal
|
June 1993 |
High-level Biosynthetic Substitution of Methionine in Proteins by its Analogs 2-Aminohexanoic Acid, Selenomethionine, Telluromethionine and Ethionine in Escherichia coli
|
journal
|
June 1995 |
Bioincorporation of telluromethionine into proteins: a promising new approach for X-ray structure analysis of proteins
|
journal
|
July 1997 |
Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: Structure and stability of the per-thiaproline mutant of annexin V
|
journal
|
January 1998 |
Enzyme-Linked Immunosorbent Assay (Elisa) for Detection of Human Reovirus-like Agent of Infantile Gastroenteritis
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journal
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August 1977 |
Probing Protein Structure and Function with an Expanded Genetic Code
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journal
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March 1995 |
Site-Specific Protein Modification Using a Ketone Handle
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journal
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January 1996 |
Absolute configuration of the enantiomers of 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline (chloroquine)
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journal
|
March 1988 |
Enlarging the Amino Acid Set of Escherichia coli by Infiltration of the Valine Coding Pathway
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journal
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April 2001 |
Unnatural amino acids as probes of protein structure and function
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journal
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December 2000 |
Incorporation of Trifluoromethionine into a Phage Lysozyme: Implications and a New Marker for Use in Protein 19 F NMR †
|
journal
|
March 1997 |
Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis
|
journal
|
November 1995 |
[15] Biosynthetic method for introducing unnatural amino acids site-specifically into proteins
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book
|
January 1991 |
Site-specific incorporation of novel backbone structures into proteins
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journal
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January 1992 |
Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel
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journal
|
January 1999 |
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
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journal
|
September 1990 |
Major tyrosine identity determinants in Methanococcus jannaschii and Saccharomyces cerevisiae tRNA Tyr are conserved but expressed differently : tRNA identity for
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journal
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February 2001 |
Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface.
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journal
|
November 1993 |
Aminoacyl-tRNA synthetases: Versatile players in the changing theater of translation
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journal
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November 2002 |
Synthesis of Derivatives of Glutamine as Model Substrates for Anti-tumor Agents
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journal
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July 1959 |
Expansion of the genetic code: Site-directed p-fluoro-phenylalanine incorporation in Escherichia coli
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journal
|
February 1998 |
A set of plasmids constitutively producing different RNA levels in Escherichia coli
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journal
|
July 1999 |
Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins
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journal
|
October 1997 |
Modification of the amino acid specificity of tyrosyl-tRNA synthetase by protein engineering
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journal
|
March 1993 |
Aspartate identity of transfer RNAs
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journal
|
January 1996 |
Universal rules and idiosyncratic features in tRNA identity
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journal
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November 1998 |
Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine
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journal
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January 1997 |
A Mutant Escherichia coli Tyrosyl-tRNA Synthetase Utilizes the Unnatural Amino Acid Azatyrosine More Efficiently than Tyrosine
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journal
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September 2000 |
Barnase and barstar: Expression of its cloned inhibitor permits expression of a cloned ribonuclease
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journal
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August 1988 |
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene
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journal
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October 2001 |
Incorporation of Nonnatural Amino Acids Into Proteins
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journal
|
June 2004 |
An unnatural base pair for incorporating amino acid analogs into proteins
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journal
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February 2002 |
Efficient Incorporation of Nonnatural Amino Acids with Large Aromatic Groups into Streptavidin in In Vitro Protein Synthesizing Systems
|
journal
|
January 1999 |
Relaxing the substrate specificity of an aminoacyl-tRNA synthetase allows in vitro and in vivo synthesis of proteins containing unnatural amino acids
|
journal
|
May 1995 |
Substrate Specificity Is Determined by Amino Acid Binding Pocket Size in Escherichia coli Phenylalanyl-tRNA Synthetase
|
journal
|
June 1994 |
Strategies for in vitro and in vivo translation with non-natural amino acids
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journal
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December 1996 |
Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme
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journal
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July 1998 |
Protein-protein interaction: a genetic selection for compensating mutations at the barnase-barstar interface.
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journal
|
March 1996 |
A cell-free protein synthesis system as an investigational tool for the translation stop processes
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journal
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April 2002 |
An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system
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journal
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July 2002 |
Protein Engineering by In Vivo Incorporation of Non-Natural Amino Acids: Control of Incorporation of Methionine Analogues by Methionyl-tRNA Synthetase
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journal
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November 2000 |
693. A new synthesis of glutamine and of γ-dipeptides of glutamic acid from phthalylated intermediates
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journal
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January 1949 |
Human Tyrosyl-tRNA Synthetase Shares Amino Acid Sequence Homology with a Putative Cytokine
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journal
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May 1997 |
Construction of Escherichia coli amber suppressor tRNA genes: II. Synthesis of additional tRNA genes and improvement of suppressor efficiency
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journal
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June 1990 |
Synthetically modified DNAs as substrates for polymerases
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journal
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December 2000 |
Synthesis of 4-substituted prolines as conformationally constrained amino acid analogs
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journal
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April 1989 |
Exploiting unassigned codons in Micrococcus luteus for tRNA-based amino acid mutagenesis
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journal
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November 1997 |
Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria
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journal
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January 2001 |
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.
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journal
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November 1986 |
Evolutionary relationship between Halobacterium cutirubrum and eukaryotes determined by use of aminoacyl-tRNA synthetases as phylogenetic probes
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journal
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March 1980 |
Novel Biological Process for L-DOPA Production from L-Tyrosine by P-Hydroxyphenylacetate 3-Hydroxylase
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journal
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January 1998 |
Progress toward the evolution of an organism with an expanded genetic code
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journal
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April 1999 |
Characterization of an ‘orthogonal’ suppressor tRNA derived from E. coli tRNA2Gln
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journal
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September 1997 |
Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo
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journal
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September 1997 |
Enzyme-generated intracellular fluorescence for single-cell reporter gene analysis utilizing Escherichia coli β-glucuronidase
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journal
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August 1996 |
Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter
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journal
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March 2001 |
In vitro protein engineering using synthetic tRNAAla with different anticodons
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journal
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August 1993 |
Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of “shifty” four-base codons with a library approach in Escherichia coli
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journal
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March 2001 |
Differences in Backbone Structure between Angiotensin II Agonists and Type I Antagonists
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journal
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November 1995 |
Efforts toward Expansion of the Genetic Alphabet: DNA Polymerase Recognition of a Highly Stable, Self-Pairing Hydrophobic Base
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journal
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December 1999 |
A Novel Copper-Mediated DNA Base Pair
- Meggers, Eric; Holland, Patrick L.; Tolman, William B.
-
Journal of the American Chemical Society, Vol. 122, Issue 43, p. 10714-10715
https://doi.org/10.1021/ja0025806
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journal
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November 2000 |
Site-Directed Mutagenesis with an Expanded Genetic Code
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journal
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June 1995 |
Flash Decaging of Tyrosine Sidechains in an Ion Channel
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journal
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April 1998 |
Noninvasive Tracing of Recombinant Proteins with “Fluorophenylalanine-Fingers”
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journal
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August 2000 |
Quadruplet codons: implications for code expansion and the specification of translation step size
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journal
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April 2000 |
Mutational Analysis of Invariant Valine B12 in Insulin: Implications for Receptor Binding
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journal
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November 2000 |
2 .ANG. Resolution Structure of DppA, a Periplasmic Dipeptide Transport/Chemosensory Receptor
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journal
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December 1995 |
A synthetic IgG-binding domain based on staphylococcal protein A
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journal
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January 1987 |
A general method for site-specific incorporation of unnatural amino acids into proteins
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journal
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April 1989 |
Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells
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journal
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April 1995 |
Rational Design of an Unnatural Base Pair with Increased Kinetic Selectivity
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journal
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September 2000 |
Efforts toward the Expansion of the Genetic Alphabet: Information Storage and Replication with Unnatural Hydrophobic Base Pairs
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journal
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April 2000 |
Co-Expression of Yeast Amber Suppressor tRNATyr and Tyrosyl-tRNA Synthetase in Escherichia coli: Possibility to Expand the Genetic Code
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journal
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December 1998 |
Changing the Amino Acid Specificity of Yeast Tyrosyl-tRNA Synthetase by Genetic Engineering
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journal
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September 2001 |
Glycine tRNA mutants with normal anticodon loop size cause -1 frameshifting.
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journal
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October 1989 |
Phage selection for site-specific incorporation of unnatural amino acids into proteins in vivo
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journal
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September 2001 |
A New Orthogonal Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for Evolving an Organism with an Expanded Genetic Code
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journal
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September 2000 |
Transport and Hydrolysis of Antibacterial Peptide Analogues in Escherichia coli: Backbone-modified Aminoxy Peptides
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journal
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September 1984 |
Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet
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journal
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January 1990 |
An Engineered Tetrahymena tRNA Gln for in Vivo Incorporation of Unnatural Amino Acids into Proteins by Nonsense Suppression
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journal
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September 1996 |
Directed evolution of the site specificity of Cre recombinase
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journal
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March 2002 |
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity
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journal
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September 2002 |
5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis
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journal
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January 1988 |
Unprotected Peptides as Building Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages
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journal
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April 1995 |
Efficient introduction of aryl bromide functionality into proteins in vivo
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journal
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February 2000 |
Region of a Conserved Sequence Motif in a Class II tRNA Synthetase Needed for Transfer of an Activated Amino Acid to an RNA Substrate
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journal
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May 1994 |
Libraries of hybrid proteins from distantly related sequences
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journal
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May 2001 |
Compilation of tRNA sequences and sequences of tRNA genes
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journal
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January 1998 |
Major Anticodon-binding Region Missing from an Archaebacterial tRNA Synthetase
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journal
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December 1999 |
Quisqualic acid analogs: synthesis of .beta.-heterocyclic 2-aminopropanoic acid derivatives and their activity at a novel quisqualate-sensitized site
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journal
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November 1992 |
Crystal structure of yeast phenylalanine transfer RNA: I. Crystallographic refinement
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journal
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August 1978 |
Enzymatic incorporation of a new base pair into DNA and RNA
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journal
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October 1989 |
Efforts toward Expansion of the Genetic Alphabet: Replication of DNA with Three Base Pairs
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journal
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August 2001 |
Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability
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journal
|
April 2001 |
Probing the Structure and Function of the Tachykinin Neurokinin-2 Receptor through Biosynthetic Incorporation of Fluorescent Amino Acids at Specific Sites
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journal
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August 1996 |
Efficient introduction of alkene functionality into proteins in vivo
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journal
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May 1998 |
Efficient Incorporation of Unsaturated Methionine Analogues into Proteins in Vivo
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journal
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February 2000 |
Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant
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journal
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January 1998 |
A general approach for the generation of orthogonal tRNAs
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journal
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September 2001 |
A New Functional Suppressor tRNA/Aminoacyl−tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins
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journal
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May 2000 |
Expanding the Genetic Code of Escherichia coli
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journal
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April 2001 |
Adding l-3-(2-Naphthyl)alanine to the Genetic Code of E. coli
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journal
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March 2002 |
A binding protein for l-glutamine and its relation to active transport in E. coli
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journal
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February 1971 |
Rescuing an essential enzyme-RNA complex with a non-essential appended domain
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journal
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May 1997 |
Translational efficiency of transfer RNA's: uses of an extended anticodon
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journal
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November 1982 |
Quantitation of Transcription and Clonal Selection of Single Living Cells with -Lactamase as Reporter
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journal
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January 1998 |
Aminoacyl-tRNA synthetases database
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journal
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January 2001 |
IA, database of known ligands of aminoacyl-tRNA synthetases
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journal
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September 2007 |