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Title: Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

Journal Article · · Applied Radiation and Isotopes
 [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States)
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In this study, we aim to directly measure the specific activity (SA) of the carbon-11 cyanide ([11C]CN¯) produced by our in-house built automated [11C]HCN production system and to identify the major sources of 12C-cyanide (12CN¯). The [11C]CN¯ is produced from [11C]CO2, which is generated by the 14N(p,α)11C nuclear reaction using a cyclotron. Direct measurement of cyanide concentrations was accomplished using a relatively inexpensive, and easy to use ion selective electrode (ISE) which offered an appropriate range of sensitivity for detecting mass. Multiple components of the [11C]HCN production system were isolated in order to determine their relative contributions to 12CN¯ mass. It was determined that the system gases were responsible for approximately 30% of the mass, and that the molecular sieve/nickel furnace unit contributed approximately 70% of the mass. Beam on target (33 µA for 1 and 10 min) did not contribute significantly to the mass. Additionally, we compared the SA of our [11C]HCN precursor determined using the ISE to the SA of our current [11C]CN¯ derived radiotracers determined by HPLC to assure there was no significant difference between the two methods. These results are the first reported use of an ion selective electrode to determine the SA of no-carrier-added cyanide ion, and clearly show that it is a valuable, inexpensive and readily available tool suitable for this purpose.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
AC02-98CH10886
OSTI ID:
1221753
Alternate ID(s):
OSTI ID: 1250917
Report Number(s):
BNL-108378-2015-JA; R&D Project: 06218; KP1602010
Journal Information:
Applied Radiation and Isotopes, Vol. 102, Issue C; ISSN 0969-8043
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 3 works
Citation information provided by
Web of Science

References (20)

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Related Subjects

42 ENGINEERING
carbon-11 cyanide
automated [11C]HCN production system
micro ion selective electrode
specific activity