Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

Shea, Colleen; Alexoff, David L.; Kim, Dohyun; Hoque, Ruma; Schueller, Michael J.; Fowler, Joanna S.; Qu, Wenchao

doi:10.1016/j.apradiso.2015.04.014

Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

Journal Article · Sat Apr 25 00:00:00 EDT 2015 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2015.04.014· OSTI ID:1221753

Shea, Colleen ^[1]; Alexoff, David L. ^[1]; Kim, Dohyun ^[1]; Hoque, Ruma ^[1]; Schueller, Michael J. ^[1]; Fowler, Joanna S. ^[1]; Qu, Wenchao ^[1]

Brookhaven National Lab. (BNL), Upton, NY (United States)

In this study, we aim to directly measure the specific activity (SA) of the carbon-11 cyanide ([¹¹C]CN¯) produced by our in-house built automated [¹¹C]HCN production system and to identify the major sources of ¹²C-cyanide (¹²CN¯). The [¹¹C]CN¯ is produced from [¹¹C]CO₂, which is generated by the ¹⁴N(p,α)¹¹C nuclear reaction using a cyclotron. Direct measurement of cyanide concentrations was accomplished using a relatively inexpensive, and easy to use ion selective electrode (ISE) which offered an appropriate range of sensitivity for detecting mass. Multiple components of the [¹¹C]HCN production system were isolated in order to determine their relative contributions to ¹²CN¯ mass. It was determined that the system gases were responsible for approximately 30% of the mass, and that the molecular sieve/nickel furnace unit contributed approximately 70% of the mass. Beam on target (33 µA for 1 and 10 min) did not contribute significantly to the mass. Additionally, we compared the SA of our [¹¹C]HCN precursor determined using the ISE to the SA of our current [¹¹C]CN¯ derived radiotracers determined by HPLC to assure there was no significant difference between the two methods. These results are the first reported use of an ion selective electrode to determine the SA of no-carrier-added cyanide ion, and clearly show that it is a valuable, inexpensive and readily available tool suitable for this purpose.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC02-98CH10886

OSTI ID:: 1221753

Alternate ID(s):: OSTI ID: 22473736
OSTI ID: 1250917

Report Number(s):: BNL--108378-2015-JA; KP1602010

Journal Information:: Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Journal Issue: C Vol. 102; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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42 ENGINEERING
automated [11C]HCN production system
carbon-11 cyanide
micro ion selective electrode
specific activity

Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide

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