Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes

Journal Article · Wed Nov 01 04:00:00 EST 1995 · Life Sciences

OSTI ID:121310

Strecker, R E; Eberle, W F ^[1]; Ashby, Jr, C R ^[2]

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1. State Univ. of New York, Stony Brook, NY (United States)
2. Brookhaven National Lab., Upton, NY (United States)

Rats of the Lewis (LEW) strain show a greater preference for drugs of abuse than do Fisher 344 (F344) rats. The in vivo microdialysis procedure was used to examine basal and cocaine-evoked extracellular (EC) levels of dopamine (DA), DOPAC, and HVA in the nucleus accumbens (NAc) of F344 and LEW rats. The basal EC levels of the DA metabolites DOPAC and HVA in the NAc were markedly lower in LEW than in F344 rats. Although the increase in ECDA after 3, 10 or 30 mg/kg, i/p. of cocaine was similar in both strains, LEW rats had a smaller peak DA elevation followed by a slower return to basal DA levels at the 30 mg/kg dose. The neurochemical differences observed may contribute to the strain differences in the behavioral response to cocaine. 20 refs., 3 figs.

• Research Organization: Brookhaven National Laboratory (BNL), Upton, NY
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 121310
• Journal Information: Life Sciences, Journal Name: Life Sciences Journal Issue: 6 Vol. 56; ISSN 0024-3205; ISSN LIFSAK
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ANIMAL CELLS
BIOLOGICAL EFFECTS
CHEMICAL COMPOSITION
COCAINE
DOPAMINE
ECOLOGICAL CONCENTRATION
IN VIVO
RATS
VARIATIONS