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Title: Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes

Abstract

Rats of the Lewis (LEW) strain show a greater preference for drugs of abuse than do Fisher 344 (F344) rats. The in vivo microdialysis procedure was used to examine basal and cocaine-evoked extracellular (EC) levels of dopamine (DA), DOPAC, and HVA in the nucleus accumbens (NAc) of F344 and LEW rats. The basal EC levels of the DA metabolites DOPAC and HVA in the NAc were markedly lower in LEW than in F344 rats. Although the increase in ECDA after 3, 10 or 30 mg/kg, i/p. of cocaine was similar in both strains, LEW rats had a smaller peak DA elevation followed by a slower return to basal DA levels at the 30 mg/kg dose. The neurochemical differences observed may contribute to the strain differences in the behavioral response to cocaine. 20 refs., 3 figs.

Authors:
;  [1];  [2]
  1. State Univ. of New York, Stony Brook, NY (United States)
  2. Brookhaven National Lab., Upton, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY
OSTI Identifier:
121310
DOE Contract Number:
AC02-76CH00016
Resource Type:
Journal Article
Resource Relation:
Journal Name: Life Sciences; Journal Volume: 56; Journal Issue: 6; Other Information: PBD: 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; COCAINE; BIOLOGICAL EFFECTS; DOPAMINE; ECOLOGICAL CONCENTRATION; ANIMAL CELLS; CHEMICAL COMPOSITION; RATS; VARIATIONS; IN VIVO

Citation Formats

Strecker, R.E., Eberle, W.F., and Ashby, C.R. Jr. Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes. United States: N. p., 1995. Web.
Strecker, R.E., Eberle, W.F., & Ashby, C.R. Jr. Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes. United States.
Strecker, R.E., Eberle, W.F., and Ashby, C.R. Jr. Wed . "Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes". United States. doi:.
@article{osti_121310,
title = {Extracellular dopamine and its metabolites in the nucleus accumbens of Fisher and Lewis rats: Basal levels and cocaine-induced changes},
author = {Strecker, R.E. and Eberle, W.F. and Ashby, C.R. Jr.},
abstractNote = {Rats of the Lewis (LEW) strain show a greater preference for drugs of abuse than do Fisher 344 (F344) rats. The in vivo microdialysis procedure was used to examine basal and cocaine-evoked extracellular (EC) levels of dopamine (DA), DOPAC, and HVA in the nucleus accumbens (NAc) of F344 and LEW rats. The basal EC levels of the DA metabolites DOPAC and HVA in the NAc were markedly lower in LEW than in F344 rats. Although the increase in ECDA after 3, 10 or 30 mg/kg, i/p. of cocaine was similar in both strains, LEW rats had a smaller peak DA elevation followed by a slower return to basal DA levels at the 30 mg/kg dose. The neurochemical differences observed may contribute to the strain differences in the behavioral response to cocaine. 20 refs., 3 figs.},
doi = {},
journal = {Life Sciences},
number = 6,
volume = 56,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 1995},
month = {Wed Nov 01 00:00:00 EST 1995}
}