Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase
Mutants of toluene o-xylene monooxygenase are demonstrated to oxidize ethylene to ethylene oxide in vivo at yields of >99%. The best mutant increases ethylene oxidation activity by >5500-fold relative to the native enzyme. This is the first report of a recombinant enzyme capable of carrying out this industrially significant chemical conversion.
- Sponsoring Organization:
- USDOE Advanced Research Projects Agency - Energy (ARPA-E)
- DOE Contract Number:
- AR0000429
- OSTI ID:
- 1211269
- Journal Information:
- ChemComm, Journal Name: ChemComm Journal Issue: 12 Vol. 51; ISSN 1359-7345
- Country of Publication:
- United States
- Language:
- English
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