Modified normal-phase ion-pair chromatographic methods for the facile separation and purification of imidazolium-based ionic compounds

Journal Article · Wed Jul 04 04:00:00 EDT 2012 · Tetrahedron Letters

DOI:https://doi.org/10.1016/j.tetlet.2012.04.104· OSTI ID:1211102

Urban, ND; Schenkel, MR; Robertson, LA; Noble, RD; Gin, DL

lmidazolium- and oligo(imidazolium)-based ionic organic compounds are important in the design of room-temperature ionic liquid materials; however, the chromatographic analysis and separation of such compounds are often difficult. A convenient and inexpensive method for effective thin-layer chromatography (TLC) analysis and column chromatography separation of imidazolium-based ionic compounds is presented. Normal-phase ion-pair TLC is used to effectively analyze homologous mixtures of these ionic compounds. Subsequent separation of the mixtures is performed using ion-pair flash chromatography on normal-phase silica gel, yielding high levels of recovery. This method also results in a complete exchange of the counter anion on the imidazolium compounds to the anion of the ion-pair reagent. (C) 2012 Elsevier Ltd. All rights reserved.

• Sponsoring Organization: USDOE Advanced Research Projects Agency - Energy (ARPA-E)
• DOE Contract Number: AR0000098
• OSTI ID: 1211102
• Journal Information: Tetrahedron Letters, Journal Name: Tetrahedron Letters Journal Issue: 27 Vol. 53; ISSN 0040-4039
• Country of Publication: United States
• Language: English