A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood

Journal Article · Wed Jan 01 00:00:00 EST 2003 · Journal of Theoretical Medicine

DOI:https://doi.org/10.1080/10273660412331317415· OSTI ID:1198219

Anand, M. ^[1]; Rajagopal, K. ^[2]; Rajagopal, K. R. ^[1]

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1. Department of Mechanical Engineering, Texas A & M University, College Station, TX 77843, USA
2. Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA

Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating the response of blood to external stimuli. To date, a comprehensive model for clot formation and dissolution, that takes into account the biochemical, medical and rheological factors, has not been put into place, the existing models emphasizing either one or the other of the factors. In this paper, after discussing the various biochemical, physiologic and rheological factors at some length, we develop a model for clot formation and dissolution that incorporates many of the relevant crucial factors that have a bearing on the problem. The model, though just a first step towards understanding a complex phenomenon, goes further than previous models in integrating the biochemical, physiologic and rheological factors that come into play.

• Sponsoring Organization: USDOE
• OSTI ID: 1198219
• Journal Information: Journal of Theoretical Medicine, Journal Name: Journal of Theoretical Medicine Vol. 5 Journal Issue: 3-4; ISSN 1027-3662
• Publisher: Hindawi Publishing Corporation
• Country of Publication: Country unknown/Code not available
• Language: English