Photochemical reactions of metal nitrosyl complexes. Mechanisms of NO reactions with biologically relevant metal centers

Journal Article · Mon Jan 01 00:00:00 EST 2001 · International Journal of Photoenergy

DOI:https://doi.org/10.1155/S1110662X01000204· OSTI ID:1198211

Ford, Peter C. ^[1]

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1. Department of Chemistry, University of California, Santa Barbara, CA 93106, USA

The discoveries that nitric oxide (a.k.a. nitrogen monoxide) serves important roles in mammalian bioregulation and immunology have stimulated intense interest in the chemistry and biochemistry of NO and derivatives such as metal nitrosyl complexes. Also of interest are strategies to deliver NO to biological targets on demand. One such strategy would be to employ a precursor which displays relatively low thermal reactivity but is photochemically active to release NO. This proposition led us to investigate laser flash and continuous photolysis kinetics of nitrosyl complexes such as the Roussin's iron-sulfur-nitrosyl cluster anions ${\text{Fe}}_{\text{2}}{\text{S}}_{\text{2}}{\left(\text{NO}\right)}_{4}2-$ and ${\text{Fe}}_{\text{4}}{\text{S}}_{\text{3}}{\left(\text{NO}\right)}_7-$ and several ruthenium salen and porphyrin nitrosyls. These include studies using metal-nitrosyl photochemistry as a vehicle for delivering NO to hypoxic cell cultures in order to sensitize $\gamma$ -radiation damage. Also studied were the rates and mechanisms of NO “on” reactions with model water soluble heme compounds, the ferriheme protein met-myoglobin and various ruthenium complexes using ns laser flash photolysis techniques. An overview of these studies is presented.

• Sponsoring Organization: USDOE
• Grant/Contract Number: FG-05-91ER79039
• OSTI ID: 1198211
• Journal Information: International Journal of Photoenergy, Journal Name: International Journal of Photoenergy Vol. 3 Journal Issue: 3; ISSN 1110-662X
• Publisher: Hindawi Publishing Corporation
• Country of Publication: Egypt
• Language: English