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Title: Apparent Tradeoff of Higher Activity in MMP-12 for Enhanced Stability and Flexibility in MMP-3

Journal Article · · Biophysical Journal

Sponsoring Organization:
USDOE
OSTI ID:
1198111
Journal Information:
Biophysical Journal, Journal Name: Biophysical Journal Vol. 99 Journal Issue: 1; ISSN 0006-3495
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 11 works
Citation information provided by
Web of Science

References (50)

A relationship between protein stability and protein function. journal January 1995
The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases journal February 1996
Cloning, Expression, Purification, and Characterization of Rat MMP-12 journal March 2001
Conformational variability of matrix metalloproteinases: Beyond a single 3D structure journal April 2005
Hydrogen exchange and protein folding journal February 1998
Fast Time Scale Dynamics of Protein Backbones:  NMR Relaxation Methods, Applications, and Functional Consequences journal May 2006
Crystal structure of the stromelysin catalytic domain at 2.0 Å resolution: inhibitor-induced conformational changes 1 1Edited by R. Huber journal October 1999
Selective Hydrolysis of Triple-helical Substrates by Matrix Metalloproteinase-2 and -9 journal May 2003
An improved experimental system for determining small folding entropy changes resulting from proline to alanine substitutions journal September 2005
An NMR Perspective on Enzyme Dynamics journal August 2006
Structural Bases of Stability–function Tradeoffs in Enzymes journal August 2002
Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx journal October 2008
Blood–brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation journal July 2006
Conformational entropy in molecular recognition by proteins journal July 2007
Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme journal May 2004
Propagation of experimental uncertainties using the Lipari-Szabo model-free analysis of protein dynamics journal November 1998
Triple-Helical Peptide Analysis of Collagenolytic Protease Activity journal January 2002
Mapping Chemical Exchange in Proteins with MW > 50 kD journal July 2003
Assignments, secondary structure and dynamics of the inhibitor-free catalytic fragment of human fibroblast collagenase journal July 1997
Improvement of duty-cycle heating compensation in NMR spin relaxation experiments journal October 2005
Multiple Proline Substitutions Cumulatively Thermostabilize Bacillus Cereus ATCC7064 Oligo-1,6-Glucosidase. Irrefragable Proof Supporting the Proline Rule journal December 1994
Solution Structure of Inhibitor-Free Human Metalloelastase (MMP-12) Indicates an Internal Conformational Adjustment journal December 2007
Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries journal October 2005
An improved method for distinguishing between anisotropic tumbling and chemical exchange in analysis of 15N relaxation parameters journal June 2001
[15] Thermodynamic parameters from hydrogen exchange measurements book January 1995
Stability for Function Trade-Offs in the Enolase Superfamily “Catalytic Module” , journal June 2007
Protein folding intermediates: native-state hydrogen exchange journal July 1995
Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor 1 1Edited by I. Wilson journal September 2001
Elastin fragments drive disease progression in a murine model of emphysema journal March 2006
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 Å crystal structure 1 1Edited by I. Wilson journal September 2001
Dynamics of stromelysin/inhibitor interactions studied by 15N NMR relaxation measurements: Comparison of ligand binding to the S1-S3 and S′1-S′3 subsites journal September 1999
Protein conformational stabilities can be determined from hydrogen exchange rates
  • Scholtz, J. Martin; Pace, C. Nick; Huyghues-Despointes, Beatrice M. P.
  • Nature Structural Biology, Vol. 6, Issue 10, p. 910-912 https://doi.org/10.1038/13273
journal October 1999
Characterization of the Distinct Collagen Binding, Helicase and Cleavage Mechanisms of Matrix Metalloproteinase 2 and 14 (Gelatinase A and MT1-MMP) journal October 2004
Elastin-Elastases and Inflamm-Aging book May 2007
PhosphoThr Peptide Binding Globally Rigidifies Much of the FHA Domain from Arabidopsis Receptor Kinase-Associated Protein Phosphatase, journal July 2005
Thermodynamic and Kinetic Exploration of the Energy Landscape of Borrelia burgdorferi OspA by Native-state Hydrogen Exchange journal October 2002
The magnitude of the backbone conformational entropy change in protein folding
  • D'Aquino, J. Alejandro; Gómez, Javier; Hilser, Vincent J.
  • Proteins: Structure, Function, and Genetics, Vol. 25, Issue 2 https://doi.org/10.1002/prot.1
journal June 1996
Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation journal May 1994
Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis. journal January 1995
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. journal November 1993
Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. journal December 1998
Rapid determination of enzyme kinetics from fluorescence: Overcoming the inner filter effect journal December 2007
Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase. journal April 1992
High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor journal September 2000
Hydrolysis of a Broad Spectrum of Extracellular Matrix Proteins by Human Macrophage Elastase journal May 1997
Direct measurement of dipole–dipole/CSA cross-correlated relaxation by a constant-time experiment journal July 2008
Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. journal October 1987
Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins journal September 2009
MMP-12 Catalytic Domain Recognizes Triple Helical Peptide Models of Collagen V with Exosites and High Activity journal August 2008
Increasing protein stability by improving beta-turns journal June 2009

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