Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

Chang, Katherine Noelani; Zhong, Shan; Weirauch, Matthew T.; Hon, Gary; Pelizzola, Mattia; Li, Hai; Huang, Shao-shan Carol; Schmitz, Robert J.; Urich, Mark A.; Kuo, Dwight; Nery, Joseph R.; Qiao, Hong; Yang, Ally; Jamali, Abdullah; Chen, Huaming; Ideker, Trey; Ren, Bing; Bar-Joseph, Ziv; Hughes, Timothy R.; Ecker, Joseph R.

doi:10.7554/eLife.00675

Title: Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

Journal Article · Tue Jun 11 00:00:00 EDT 2013 · eLife

DOI:https://doi.org/10.7554/eLife.00675· OSTI ID:1197659

Chang, Katherine Noelani ^[1]; Zhong, Shan ^[2]; Weirauch, Matthew T. ^[3]; Hon, Gary ^[4]; Pelizzola, Mattia ^[1]; Li, Hai ^[1]; Huang, Shao-shan Carol ^[5]; Schmitz, Robert J. ^[1]; Urich, Mark A. ^[1]; Kuo, Dwight ^[6]; Nery, Joseph R. ^[7]; Qiao, Hong ^[1]; Yang, Ally ^[3]; Jamali, Abdullah ^[1]; Chen, Huaming ^[7]; Ideker, Trey ^[8]; Ren, Bing ^[9]; Bar-Joseph, Ziv ^[10]; Hughes, Timothy R. ^[3]; Ecker, Joseph R. ^[5]

Plant Biology Laboratory, and Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, United States
Lane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States
Department of Molecular Genetics and Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, United States
Plant Biology Laboratory, and Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, United States, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, United States
Department of Bioengineering, Department of Medicine, The Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States
Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, United States
Departments of Medicine and Bioengineering, University of California, San Diego, San Diego, United States
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, United States, Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, San Diego, United States
Lane Center for Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States, Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States

The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways.

View Journal Article

Cite

Export

Save

Research Organization:: Salk Institute for Biological Studies, La Jolla, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: FG03-00ER15113, DE-FG02-04ER15517; MCB-0924871; FG02-04ER15517; FG03-00ER15113

OSTI ID:: 1197659

Alternate ID(s):: OSTI ID: 1197660; OSTI ID: 1628795

Journal Information:: eLife, Journal Name: eLife Vol. 2; ISSN 2050-084X

Publisher:: eLife Sciences Publications, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 285 works

Citation information provided by
Web of Science

References (73)

A New Class of Arabidopsis Constitutive Photomorphogenic Genes Involved in Regulating Cotyledon Development. Hou, Y.; Von Arnim, A. G.; Deng, X. W. The Plant Cell https://doi.org/10.1105/tpc.5.3.329	journal	March 1993
Multiple sequence alignment with the Clustal series of programs Chenna, R. Nucleic Acids Research, Vol. 31, Issue 13 https://doi.org/10.1093/nar/gkg500	journal	July 2003
FLOWERING LOCUS C (FLC) regulates development pathways throughout the life cycle of Arabidopsis Deng, W.; Ying, H.; Helliwell, C. A. Proceedings of the National Academy of Sciences, Vol. 108, Issue 16 https://doi.org/10.1073/pnas.1103175108	journal	April 2011
Model-based Analysis of ChIP-Seq (MACS) Zhang, Yong; Liu, Tao; Meyer, Clifford A. Genome Biology, Vol. 9, Issue 9 https://doi.org/10.1186/gb-2008-9-9-r137	journal	January 2008
Ethylene in vegetative development: a tale with a riddle: Tansley review Vandenbussche, Filip; Vaseva, Irina; Vissenberg, Kris New Phytologist, Vol. 194, Issue 4 https://doi.org/10.1111/j.1469-8137.2012.04100.x	journal	March 2012
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana Alonso, J. M.; Stepanova, Anna N.; Leisse, Thomas J. Science, Vol. 301, Issue 5633, p. 653-657 https://doi.org/10.1126/science.1086391	journal	August 2003
Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1 Boutrot, F.; Segonzac, C.; Chang, K. N. Proceedings of the National Academy of Sciences, Vol. 107, Issue 32 https://doi.org/10.1073/pnas.1003347107	journal	July 2010
Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences Berger, Michael F.; Badis, Gwenael; Gehrke, Andrew R. Cell, Vol. 133, Issue 7 https://doi.org/10.1016/j.cell.2008.05.024	journal	June 2008
Arabidopsis Seedling Growth Response and Recovery to Ethylene. A Kinetic Analysis Binder, Brad M.; O'Malley, Ronan C.; Wang, Wuyi Plant Physiology, Vol. 136, Issue 2 https://doi.org/10.1104/pp.104.050369	journal	October 2004
Negative Autoregulation Speeds the Response Times of Transcription Networks Rosenfeld, Nitzan; Elowitz, Michael B.; Alon, Uri Journal of Molecular Biology, Vol. 323, Issue 5 https://doi.org/10.1016/S0022-2836(02)00994-4	journal	November 2002
Design and analysis of ChIP-seq experiments for DNA-binding proteins Kharchenko, Peter V.; Tolstorukov, Michael Y.; Park, Peter J. Nature Biotechnology, Vol. 26, Issue 12 https://doi.org/10.1038/nbt.1508	journal	November 2008
Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays Lam, Kathy N.; van Bakel, Harm; Cote, Atina G. Nucleic Acids Research, Vol. 39, Issue 11 https://doi.org/10.1093/nar/gkq1303	journal	February 2011
Ethylene inhibits lateral root development, increases IAA transport and expression of PIN3 and PIN7 auxin efflux carriers Lewis, Daniel R.; Negi, Sangeeta; Sukumar, Poornima Development, Vol. 138, Issue 16 https://doi.org/10.1242/dev.065102	journal	July 2011
Dynamic and complex transcription factor binding during an inducible response in yeast Ni, L.; Bruce, C.; Hart, C. Genes & Development, Vol. 23, Issue 11 https://doi.org/10.1101/gad.1781909	journal	June 2009
Feedback regulation of EGFR signalling: decision making by early and delayed loops Avraham, Roi; Yarden, Yosef Nature Reviews Molecular Cell Biology, Vol. 12, Issue 2 https://doi.org/10.1038/nrm3048	journal	January 2011
Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis Sun, Yu; Fan, Xi-Ying; Cao, Dong-Mei Developmental Cell, Vol. 19, Issue 5 https://doi.org/10.1016/j.devcel.2010.10.010	journal	November 2010
Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis Zhu, Z.; An, F.; Feng, Y. Proceedings of the National Academy of Sciences, Vol. 108, Issue 30 https://doi.org/10.1073/pnas.1103959108	journal	July 2011
Profiling DNA methylation patterns using genomic tiling microarrays Lippman, Zachary; Gendrel, Anne-Valérie; Colot, Vincent Nature Methods, Vol. 2, Issue 3 https://doi.org/10.1038/nmeth0305-219	journal	March 2005
Impulse Control: Temporal Dynamics in Gene Transcription Yosef, Nir; Regev, Aviv Cell, Vol. 144, Issue 6 https://doi.org/10.1016/j.cell.2011.02.015	journal	March 2011
The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis Fang, Xuefeng; Yoon, Jae-Geun; Li, Lisha BMC Genomics, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2164-12-11	journal	January 2011
Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function Lickwar, Colin R.; Mueller, Florian; Hanlon, Sean E. Nature, Vol. 484, Issue 7393 https://doi.org/10.1038/nature10985	journal	April 2012
HOOKLESS1, an Ethylene Response Gene, Is Required for Differential Cell Elongation in the Arabidopsis Hypocotyl Lehman, Anne; Black, Robert; Ecker, Joseph R. Cell, Vol. 85, Issue 2 https://doi.org/10.1016/S0092-8674(00)81095-8	journal	April 1996
A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana: Brassinosteroid transcriptional network Yu, Xiaofei; Li, Lei; Zola, Jaroslaw The Plant Journal, Vol. 65, Issue 4 https://doi.org/10.1111/j.1365-313X.2010.04449.x	journal	January 2011
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation Menet, Jerome S.; Rodriguez, Joseph; Abruzzi, Katharine C. eLife https://doi.org/10.7554/eLife.00011.026	journal	November 2012
PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls Rozowsky, Joel; Euskirchen, Ghia; Auerbach, Raymond K. Nature Biotechnology, Vol. 27, Issue 1 https://doi.org/10.1038/nbt.1518	journal	January 2009
Short-Term Growth Responses to Ethylene in Arabidopsis Seedlings Are EIN3/EIL1 Independent Binder, Brad M.; Mortimore, Laura A.; Stepanova, Anna N. Plant Physiology, Vol. 136, Issue 2 https://doi.org/10.1104/pp.104.050393	journal	October 2004
Genome-wide transcription factor binding: beyond direct target regulation MacQuarrie, Kyle L.; Fong, Abraham P.; Morse, Randall H. Trends in Genetics, Vol. 27, Issue 4 https://doi.org/10.1016/j.tig.2011.01.001	journal	April 2011
LEAFY Target Genes Reveal Floral Regulatory Logic, cis Motifs, and a Link to Biotic Stimulus Response Winter, Cara M.; Austin, Ryan S.; Blanvillain-Baufumé, Servane Developmental Cell, Vol. 20, Issue 4 https://doi.org/10.1016/j.devcel.2011.03.019	journal	April 2011
Development of Arabidopsis whole-genome microarrays and their application to the discovery of binding sites for the TGA2 transcription factor in salicylic acid-treated plants Thibaud-Nissen, Françoise; Wu, Hank; Richmond, Todd The Plant Journal, Vol. 47, Issue 1 https://doi.org/10.1111/j.1365-313X.2006.02770.x	journal	July 2006
Identifying DNA and protein patterns with statistically significant alignments of multiple sequences Hertz, G. Z.; Stormo, G. D. Bioinformatics, Vol. 15, Issue 7 https://doi.org/10.1093/bioinformatics/15.7.563	journal	July 1999
Evidence for Network Evolution in an Arabidopsis Interactome Map Dreze, M.; Carvunis, A. -R.; Charloteaux, B. Science, Vol. 333, Issue 6042 https://doi.org/10.1126/science.1203877	journal	July 2011
Orchestration of Floral Initiation by APETALA1 Kaufmann, K.; Wellmer, F.; Muino, J. M. Science, Vol. 328, Issue 5974 https://doi.org/10.1126/science.1185244	journal	April 2010
Plant Responses to Ethylene Gas Are Mediated by SCF^EBF1/EBF2-Dependent Proteolysis of EIN3 Transcription Factor Guo, Hongwei; Ecker, Joseph R Cell, Vol. 115, Issue 6, p. 667-677 https://doi.org/10.1016/S0092-8674(03)00969-3	journal	December 2003
Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis Peng, Zhi-yu; Zhou, Xin; Li, Linchuan Nucleic Acids Research, Vol. 37, Issue suppl_1 https://doi.org/10.1093/nar/gkn873	journal	November 2008
Ethylene signaling: new levels of complexity and regulation Kendrick, Mandy D.; Chang, Caren Current Opinion in Plant Biology, Vol. 11, Issue 5 https://doi.org/10.1016/j.pbi.2008.06.011	journal	October 2008
Quantitative analysis demonstrates most transcription factors require only simple models of specificity Zhao, Yue; Stormo, Gary D. Nature Biotechnology, Vol. 29, Issue 6 https://doi.org/10.1038/nbt.1893	journal	June 2011
Diversity and Complexity in DNA Recognition by Transcription Factors Badis, G.; Berger, M. F.; Philippakis, A. A. Science, Vol. 324, Issue 5935 https://doi.org/10.1126/science.1162327	journal	May 2009
The Regulation of Aging and Longevity: A New and Complex Role of p53 Feng, Z.; Lin, M.; Wu, R. Genes & Cancer, Vol. 2, Issue 4 https://doi.org/10.1177/1947601911410223	journal	April 2011
Statistical mechanical modeling of genome-wide transcription factor occupancy data by MatrixREDUCE Foat, B. C.; Morozov, A. V.; Bussemaker, H. J. Bioinformatics, Vol. 22, Issue 14 https://doi.org/10.1093/bioinformatics/btl223	journal	July 2006
Convergence of Signaling Pathways in the Control of Differential Cell Growth in Arabidopsis Li, Hai; Johnson, Phoebe; Stepanova, Anna Developmental Cell, Vol. 7, Issue 2 https://doi.org/10.1016/j.devcel.2004.07.002	journal	August 2004
Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1 Solano, R.; Stepanova, A.; Chao, Q. Genes & Development, Vol. 12, Issue 23 https://doi.org/10.1101/gad.12.23.3703	journal	December 1998
Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis Alonso, J. M.; Stepanova, A. N.; Solano, R. Proceedings of the National Academy of Sciences, Vol. 100, Issue 5 https://doi.org/10.1073/pnas.0438070100	journal	February 2003
AGRIS: the Arabidopsis Gene Regulatory Information Server, an update Yilmaz, A.; Mejia-Guerra, M. K.; Kurz, K. Nucleic Acids Research, Vol. 39, Issue Database https://doi.org/10.1093/nar/gkq1120	journal	November 2010
ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 Repress SALICYLIC ACID INDUCTION DEFICIENT2 Expression to Negatively Regulate Plant Innate Immunity in Arabidopsis Chen, Huamin; Xue, Li; Chintamanani, Satya The Plant Cell, Vol. 21, Issue 8 https://doi.org/10.1105/tpc.108.065193	journal	August 2009
Auxin, Ethylene and Brassinosteroids: Tripartite Control of Growth in the Arabidopsis Hypocotyl De Grauwe, Liesbeth; Vandenbussche, Filip; Tietz, Olaf Plant and Cell Physiology, Vol. 46, Issue 6 https://doi.org/10.1093/pcp/pci111	journal	June 2005
A new Generation of Homology Search Tools Based on Probabilistic Inference Eddy, Sean R. Proceedings of the 20th International Conference, Genome Informatics 2009 https://doi.org/10.1142/9781848165632_0019	conference	March 2012
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks Shannon, P. Genome Research, Vol. 13, Issue 11 https://doi.org/10.1101/gr.1239303	journal	November 2003
Orchestration of the Floral Transition and Floral Development in Arabidopsis by the Bifunctional Transcription Factor APETALA2 Yant, Levi; Mathieu, Johannes; Dinh, Thanh Theresa The Plant Cell, Vol. 22, Issue 7 https://doi.org/10.1105/tpc.110.075606	journal	July 2010
Localization of the Raf-like Kinase CTR1 to the Endoplasmic Reticulum of Arabidopsis through Participation in Ethylene Receptor Signaling Complexes Gao, Zhiyong; Chen, Yi-Feng; Randlett, Melynda D. Journal of Biological Chemistry, Vol. 278, Issue 36 https://doi.org/10.1074/jbc.M305548200	journal	June 2003
Cloning and DNA-binding properties of a tobacco Ethylene-Insensitive3 (EIN3) homolog Kosugi, S. Nucleic Acids Research, Vol. 28, Issue 4 https://doi.org/10.1093/nar/28.4.960	journal	February 2000
The embryonic leaf identity gene FUSCA3 regulates vegetative phase transitions by negatively modulating ethylene-regulated gene expression in Arabidopsis Lumba, Shelley; Tsuchiya, Yuichiro; Delmas, Frederic BMC Biology, Vol. 10, Issue 1 https://doi.org/10.1186/1741-7007-10-8	journal	January 2012
EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and to promote greening of Arabidopsis seedlings Zhong, Shangwei; Zhao, Mantong; Shi, Tianying Proceedings of the National Academy of Sciences, Vol. 106, Issue 50 https://doi.org/10.1073/pnas.0907670106	journal	November 2009
Reconstructing dynamic regulatory maps Ernst, Jason; Vainas, Oded; Harbison, Christopher T. Molecular Systems Biology, Vol. 3, Issue 1 https://doi.org/10.1038/msb4100115	journal	January 2007
Target Genes of the MADS Transcription Factor SEPALLATA3: Integration of Developmental and Hormonal Pathways in the Arabidopsis Flower Kaufmann, Kerstin; Muiño, Jose M.; Jauregui, Ruy PLoS Biology, Vol. 7, Issue 4 https://doi.org/10.1371/journal.pbio.1000090	journal	April 2009
Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors Berger, Michael F.; Bulyk, Martha L. Nature Protocols, Vol. 4, Issue 3 https://doi.org/10.1038/nprot.2008.195	journal	March 2009
Characterization of SOC1’s Central Role in Flowering by the Identification of Its Upstream and Downstream Regulators Immink, Richard G. H.; Posé, David; Ferrario, Silvia Plant Physiology, Vol. 160, Issue 1 https://doi.org/10.1104/pp.112.202614	journal	July 2012
MicroRNA-Mediated Feedback and Feedforward Loops Are Recurrent Network Motifs in Mammals Tsang, John; Zhu, Jun; van Oudenaarden, Alexander Molecular Cell, Vol. 26, Issue 5 https://doi.org/10.1016/j.molcel.2007.05.018	journal	June 2007
Involvement of HLS1 in Sugar and Auxin Signaling in Arabidopsis Leaves Ohto, Masa-aki; Hayashi, Shingo; Sawa, Shinichiro Plant and Cell Physiology, Vol. 47, Issue 12 https://doi.org/10.1093/pcp/pcl027	journal	December 2006
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities Berger, Michael F.; Philippakis, Anthony A.; Qureshi, Aaron M. Nature Biotechnology, Vol. 24, Issue 11 https://doi.org/10.1038/nbt1246	journal	September 2006
The Pfam protein families database Finn, Robert D.; Mistry, Jaina; Tate, John Nucleic Acids Research, Vol. 38, Issue suppl_1 https://doi.org/10.1093/nar/gkp985	journal	November 2009
BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks Maere, S.; Heymans, K.; Kuiper, M. Bioinformatics, Vol. 21, Issue 16 https://doi.org/10.1093/bioinformatics/bti551	journal	June 2005
STAMP: a web tool for exploring DNA-binding motif similarities Mahony, S.; Benos, P. V. Nucleic Acids Research, Vol. 35, Issue Web Server https://doi.org/10.1093/nar/gkm272	journal	May 2007
Different Plant Hormones Regulate Similar Processes through Largely Nonoverlapping Transcriptional Responses Nemhauser, Jennifer L.; Hong, Fangxin; Chory, Joanne Cell, Vol. 126, Issue 3 https://doi.org/10.1016/j.cell.2006.05.050	journal	August 2006
A module of negative feedback regulators defines growth factor signaling Amit, Ido; Citri, Ami; Shay, Tal Nature Genetics, Vol. 39, Issue 4 https://doi.org/10.1038/ng1987	journal	February 2007
Changes in 5S rDNA Chromatin Organization and Transcription during Heterochromatin Establishment in Arabidopsis Mathieu, Olivier; Jasencakova, Zuzana; Vaillant, Isabelle The Plant Cell, Vol. 15, Issue 12 https://doi.org/10.1105/tpc.017467	journal	November 2003
Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1 Leyser, H. M. Ottoline; Lincoln, Cynthia A.; Timpte, Candace Nature, Vol. 364, Issue 6433 https://doi.org/10.1038/364161a0	journal	July 1993
Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis Lister, Ryan; O'Malley, Ronan C.; Tonti-Filippini, Julian Cell, Vol. 133, Issue 3 https://doi.org/10.1016/j.cell.2008.03.029	journal	May 2008
Combinatorial binding predicts spatio-temporal cis-regulatory activity Zinzen, Robert P.; Girardot, Charles; Gagneur, Julien Nature, Vol. 462, Issue 7269 https://doi.org/10.1038/nature08531	journal	November 2009
Improved detection of DNA motifs using a self-organized clustering of familial binding profiles Mahony, S.; Golden, A.; Smith, T. J. Bioinformatics, Vol. 21, Issue Suppl 1 https://doi.org/10.1093/bioinformatics/bti1025	journal	June 2005
Activation of the Ethylene Gas Response Pathway in Arabidopsis by the Nuclear Protein ETHYLENE-INSENSITIVE3 and Related Proteins Chao, Qimin; Rothenberg, Madge; Solano, Roberto Cell, Vol. 89, Issue 7, p. 1133-1144 https://doi.org/10.1016/S0092-8674(00)80300-1	journal	June 1997
Ethylene signaling in Arabidopsis involves feedback regulation via the elaborate control of EBF2 expression by EIN3 Konishi, Mineko; Yanagisawa, Shuichi The Plant Journal, Vol. 55, Issue 5 https://doi.org/10.1111/j.1365-313X.2008.03551.x	journal	September 2008
Cell Identity Regulators Link Development and Stress Responses in the Arabidopsis Root Iyer-Pascuzzi, Anjali S.; Jackson, Terry; Cui, Hongchang Developmental Cell, Vol. 21, Issue 4 https://doi.org/10.1016/j.devcel.2011.09.009	journal	October 2011
Temporal and Spatial Changes in Transcription Factor Binding and Histone Modifications at the Steroidogenic Acute Regulatory Protein ( StAR ) Locus Associated with StAR Transcription Hiroi, Hisahiko; Christenson, Lane K.; Chang, Lisa Molecular Endocrinology, Vol. 18, Issue 4 https://doi.org/10.1210/me.2003-0305	journal	April 2004

Similar Records

Molecular and Genetic Analysis of Hormone-Regulated Differential Cell Elongation in Arabidopsis

Technical Report · Thu Sep 15 00:00:00 EDT 2005 · OSTI ID:1197659

Ecker, Joseph R

Molecular and Genetic Analysis of Hormone-Regulated Differential Cell Elongation in Arabidopsis

Technical Report · Tue Dec 03 00:00:00 EST 2002 · OSTI ID:1197659

Ecker, Joseph R

Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4

Journal Article · Fri Sep 13 00:00:00 EDT 2013 · Biochemical and Biophysical Research Communications · OSTI ID:1197659

Chi, Hsiang-Cheng; Liao, Chen-Hsin; Huang, Ya-Hui; +10 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Life Sciences & Biomedicine - Other Topics

Title: Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

Citation Formats

References (73)

Similar Records

Related Subjects