Preparation of 4-amino-2,4-dioxobutanoic acid

Unkefer, Pat J.; Martinez, Rodolfo A.; Glass, David R.

Title: Preparation of 4-amino-2,4-dioxobutanoic acid

Patent · Tue Jun 02 00:00:00 EDT 2015

OSTI ID:1183457

Unkefer, Pat J.; Martinez, Rodolfo A.; Glass, David R.

A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with sodium ethoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl-2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl-2-cyano-3-hydroxybutenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with aqueous sodium hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-06NA25396

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Number(s):: 9,045,392

Application Number:: 13/828,905

OSTI ID:: 1183457

Country of Publication:: United States

Language:: English

References (29)

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Cited By (2)

Preparation of 4-amino-2,4-dioxobutanoic acid Unkefer, Pat J.; Martinez, Rodolfo A.; Glass, David R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9290443 US Patent Document 9,290,443	patent	March 2016
Preparation of 4-amino-2,4-dioxobutanoic acid Unkefer, Pat J.; Martinez, Rodolfo A.; Glass, David R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9290442 US Patent Document 9,290,442	patent	March 2016

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