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Characterisation of the binding of [ 3 H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor
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January 2004 |
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Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli
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journal
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January 2014 |
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Activation and allosteric modulation of a muscarinic acetylcholine receptor
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journal
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November 2013 |
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PRODRG : a tool for high-throughput crystallography of protein–ligand complexes
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July 2004 |
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Structure of the agonist-bound neurotensin receptor
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journal
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October 2012 |
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Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
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July 2010 |
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Hypocretin (orexin) deficiency in human narcolepsy
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January 2000 |
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Structure-based discovery of 2-adrenergic receptor ligands
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April 2009 |
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Promotion of sleep by targeting the orexin system in rats, dogs and humans
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journal
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January 2007 |
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Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, While Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and -Insensitive G-Proteins
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journal
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January 2003 |
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Fitting molecular fragments into electron density
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December 2007 |
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Narcolepsy in orexin Knockout Mice
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August 1999 |
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Crystallizing membrane proteins using lipidic mesophases
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April 2009 |
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Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial
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May 2014 |
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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
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January 1995 |
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Features and development of Coot
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March 2010 |
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[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
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Crystal Structure of an Archaeal Glycogen Synthase: INSIGHTS INTO OLIGOMERIZATION AND SUBSTRATE BINDING OF EUKARYOTIC GLYCOGEN SYNTHASES
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November 2005 |
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TLSMD web server for the generation of multi-group TLS models
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January 2006 |
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Mapping the Binding Pocket of Dual Antagonist Almorexant to Human Orexin 1 and Orexin 2 Receptors: Comparison with the Selective OX 1 Antagonist SB-674042 and the Selective OX 2 Antagonist N -Ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]- N -pyridin-3-ylmethyl-acetamide (EMPA)
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April 2010 |
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Structure and dynamics of the M3 muscarinic acetylcholine receptor
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February 2012 |
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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
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January 2010 |
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Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding
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June 2009 |
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
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Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor: EMPA: a selective antagonist of the OX2 receptor
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April 2009 |
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Extending the Applicability of the Nonlinear Poisson−Boltzmann Equation: Multiple Dielectric Constants and Multivalent Ions †
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July 2001 |
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MolProbity : all-atom structure validation for macromolecular crystallography
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December 2009 |
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Phaser crystallographic software
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July 2007 |
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Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases
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June 2009 |
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The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
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August 1999 |
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The hypocretins/orexins: integrators of multiple physiological functions: Orexins integrate physiological functions
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December 2013 |
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Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists
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journal
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September 2011 |
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GPCR Engineering Yields High-Resolution Structural Insights into 2-Adrenergic Receptor Function
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October 2007 |
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Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
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October 2010 |
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Structure of a β1-adrenergic G-protein-coupled receptor
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June 2008 |
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Rapid Context-Dependent Ligand Desolvation in Molecular Docking
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August 2010 |
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
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March 2012 |
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Comparative Performance Assessment of the Conformational Model Generators Omega and Catalyst: A Large-Scale Survey on the Retrieval of Protein-Bound Ligand Conformations
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journal
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July 2006 |
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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
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journal
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June 2003 |
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Structure of a nanobody-stabilized active state of the β2 adrenoceptor
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January 2011 |
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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
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journal
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December 2009 |
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Activation of the β 2 -Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6
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journal
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May 2001 |
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DSX : A Knowledge-Based Scoring Function for the Assessment of Protein–Ligand Complexes
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journal
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October 2011 |
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Amino and Carboxyl Terminal Modifications to Facilitate the Production and Purification of a G Protein-Coupled Receptor
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October 1995 |
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Discovery and development of orexin receptor antagonists as therapeutics for insomnia: Development of orexin receptor antagonists for insomnia
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December 2013 |
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Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
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February 1998 |
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Automated Docking Screens: A Feasibility Study
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September 2009 |