Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2
A stable boronated (10B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [10B]Na4B24H22S2, at a dose of about 200 $$\mu$$g 10B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 $$\mu$$g 10B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of 10B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of 10B in the tumor.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- The United States of America as represented by the United States Department of Energy (Washington, DC)
- Patent Number(s):
- H000505
- Application Number:
- 06/838494
- OSTI ID:
- 1176581
- Resource Relation:
- Patent File Date: 1986 Mar 11
- Country of Publication:
- United States
- Language:
- English
Boron Neutron Capture Therapy of Cerebral Gliomas
|
journal | January 1975 |
A revised boron-neutron capture therapy for malignant brain tumours
|
journal | January 1973 |
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