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Isolated nucleic acids encoding antipathogenic polypeptides and uses thereof

Patent ·
OSTI ID:1176246
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Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from fungal fermentation broths. Nucleic acids that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention are also disclosed.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
Pioneer Hi-Bred International, Inc. (Johnston, IA); E.I. du Pont de Nemours and Company (Wilmington, DE); The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,700,832
Application Number:
12/265,461
OSTI ID:
1176246
Country of Publication:
United States
Language:
English

References (14)

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Antifungal Protein PAF Severely Affects the Integrity of the Plasma Membrane of Aspergillus nidulans and Induces an Apoptosis-Like Phenotype journal June 2005
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Isolation and Characterization of a Novel Antifungal Peptide from Aspergillus niger journal October 1999
Functional Analysis of Conserved Histidines in ADP-Glucose Pyrophosphorylase from Escherichia coli journal March 1998
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Genetically engineered stem rust resistance in barley using the Rpg1 gene journal December 2002
Functional Domain Analysis of the Yeast ABC Transporter Ycf1p by Site-directed Mutagenesis journal August 1999
Sensitivity of different Zygomycetes to the Penicillium chrysogenum antifungal protein (PAF): Effects of PAF on Zygomycetes journal April 2005
New insights into the target site and mode of action of the antifungal protein of Aspergillus giganteus journal January 2005
Unexpected homology between inducible cell wall protein QID74 of filamentous fungi and BR3 salivary protein of the insect Chironomus journal May 1998
Purification, Characterisation and cDNA Cloning of an Antimicrobial Peptide from Macadamia Integrifolia journal March 1997

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59 BASIC BIOLOGICAL SCIENCES