skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Engineering of metabolic control

Patent ·
OSTI ID:1175947

The invention features a method of producing heterologous molecules in cells under the regulatory control of a metabolite and metabolic flux. The method can enhance the synthesis of heterologous polypeptides and metabolites.

Research Organization:
Food Industry Research and Development Institute, Hsinchu (Taiwan)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-98ER20298
Assignee:
Food Industry Research and Development Institute (Hsinchu, TW)
Patent Number(s):
7,122,341
Application Number:
10/048,186
OSTI ID:
1175947
Resource Relation:
Patent File Date: 2000 Jul 27
Country of Publication:
United States
Language:
English

References (26)

Metabolic engineering of Escherichia coli to enhance recombinant protein production through acetate reduction journal July 1995
Pathway engineering for production of aromatics in Escherichia coli: Confirmation of stoichiometric analysis by independent modulation of AroG, TktA, and Pps activities journal May 1995
Metabolic engineering of the terpenoid biosynthetic pathway of Escherichia coli for production of the carotenoids β-carotene and zeaxanthin journal September 1999
The biotechnological potential and design of novel carotenoids by gene combination in Escherichia coli journal June 1999
Increased Carotenoid Production by the Food YeastCandida utilis through Metabolic Engineering of the Isoprenoid Pathway journal July 1998
Communication Modules in Bacterial Signaling Proteins journal December 1992
Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli journal June 1997
The Pseudomonas aeruginosa rhlG Gene Encodes an NADPH-Dependent β-Ketoacyl Reductase Which Is Specifically Involved in Rhamnolipid Synthesis journal September 1998
The use of elements of the E. coli Ntr-system for the design of an optimized recombinant expression system for high cell density cultivations journal October 1999
Engineering novel carotenoids in microorganisms journal June 2000
Improving lycopene production in Escherichia coli by engineering metabolic control journal May 2000
Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase journal April 2000
Improved expression of human interleukin-2 in high-cell-density fermentor cultures of Escherichia coli K-12 by a phosphotransacetylase mutant. journal January 1990
Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12. journal January 1997
Production of zeaxanthin in Escherichia coli transformed with different carotenogenic plasmids journal August 1997
The ability of Escherichia coli O157:H7 to decrease its intracellular pH and resist the toxicity of acetic acid journal April 1997
Formation of recombinant proteins in Escherichia coli under control of a nitrogen regulated promoter at low and high cell densities journal August 1996
Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts journal January 1998
Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli. journal January 1992
Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol journal November 1997
Is acetyl phosphate a global signal in Escherichia coli? journal January 1993
Protein histidine kinases and signal tranduction in prokaryotes and eukaryotes journal April 1994
Expression of glnA in Escherichia coli is regulated at tandem promoters. journal April 1985
Antisense treatment for psoriasis journal May 2000
DNA binding and oligomerization of NtrC studied by fluorescence anisotropy and fluorescence correlation spectroscopy journal March 1998
[24] Analysis of two-component signal transduction systems involved in transcriptional regulation book January 1996

Similar Records

Engineering of metabolic control
Patent · Tue Mar 16 00:00:00 EST 2004 · OSTI ID:1175947
Role of glycolytic intermediate in regulation: Improving lycopene production in Escherichia coli by engineering metabolic control
Technical Report · Fri Jun 01 00:00:00 EDT 2001 · OSTI ID:1175947
Control of Carbon Allocation in Phenylpropanoid Metabolism
Technical Report · Sun Nov 21 00:00:00 EST 2021 · OSTI ID:1175947

Related Subjects

60 APPLIED LIFE SCIENCES