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Title: DNA encoding a DNA repair protein

Patent ·
OSTI ID:1175872
; ; ;

An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

Research Organization:
Wisconsin Alumni Research Foundation, Madison, WI (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
4459-011502
Assignee:
Wisconsin Alumni Research Foundation
Patent Number(s):
7,091,037
Application Number:
09/837,602
OSTI ID:
1175872
Country of Publication:
United States
Language:
English

References (14)

Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue. journal November 1990
Targeting the mouse genome: a compendium of knockouts (part I) journal June 1995
Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities. journal March 1988
Knockout Mice journal April 1996
Transgenic and knock-out models for studying DNA repair journal January 1995
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. journal October 1997
Xpaknockout mice journal October 1996
Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. journal September 1996
Deciphering the message in protein sequences: tolerance to amino acid substitutions journal March 1990
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells journal August 1997
Targeting the mouse genome: a compendium of knockouts (part II) journal July 1995
Isolation and Characterization of the Human MRE11 Homologue journal September 1995
Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome journal May 1998
Expression of RAD4 Gene of Saccharomyces cerevisiae That Can Be Propagated in Escherichia coli without Inactivation journal May 1993

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60 APPLIED LIFE SCIENCES