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Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs

Patent ·
OSTI ID:1175717
; ; ;
Laser tissue welding can be achieved using tunable Cr.sup.4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.
Research Organization:
The Research Foundation of The City University of New York, New York, NY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-98ER62560
Assignee:
The Research Foundation of The City University of New York (New York, NY)
Patent Number(s):
7,033,348
Application Number:
10/119,914
OSTI ID:
1175717
Country of Publication:
United States
Language:
English

References (9)

Reinforcement of Colonic Anastomoses With a Laser and Dye–Enhanced Fibrinogen journal November 1990
Laser tissue welding: A comprehensive review of current and future journal January 1995
Myristoyl Gelatin as a Sealant for Dacron Vascular Prostheses journal April 1997
Dye-enhanced laser tissue welding journal January 1989
Biological effects and cytotoxicity of the composite composed by tricalcium phosphate and glutaraldehyde cross-linked gelatin journal May 1998
Conformational Changes and Some Functional Characteristics of Gelatin Esterified with Fatty Acid journal June 2001
Laser activation of tissue sealant in hand-sewn canine esophageal closure journal April 1992
Skin Closure with Dye-Enhanced Laser Welding and Fibrinogen journal January 1991
Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser journal May 1990

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Related Subjects

60 APPLIED LIFE SCIENCES