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Structural and Functional Study of d-Glucuronyl C5-epimerase

Journal Article · · J. Biol. Chem.
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
FOREIGN
OSTI ID:
1172408
Journal Information:
J. Biol. Chem., Journal Name: J. Biol. Chem. Journal Issue: (8) ; 02, 2015 Vol. 290
Country of Publication:
United States
Language:
ENGLISH

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Using Engineered 2- O -Sulfotransferase to Determine the Activity of Heparan Sulfate C 5 -epimerase and Its Mutants journal January 2010
Uncovering Biphasic Catalytic Mode of C 5 -epimerase in Heparan Sulfate Biosynthesis journal April 2012
A Novel Bacterial Enzyme with d-Glucuronyl C5-epimerase Activity journal July 2013
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Identification of the Active Site of DS-epimerase 1 and Requirement of N -Glycosylation for Enzyme Function journal November 2008
Lack ofl-Iduronic Acid in Heparan Sulfate Affects Interaction with Growth Factors and Cell Signaling journal March 2009
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Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival journal June 2011
Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells journal January 2010
Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme Glucuronyl C5-Epimerase journal March 2010

Cited By (7)

Heparin and related polysaccharides: synthesis using recombinant enzymes and metabolic engineering journal July 2015
The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate journal November 2016
Enzyme overexpression – an exercise toward understanding regulation of heparan sulfate biosynthesis journal August 2016
Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase journal March 2019
Pharmacology of Heparin and Related Drugs journal November 2015
Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard? journal March 2015
Glycosaminoglycan-Protein Interactions by Nuclear Magnetic Resonance (NMR) Spectroscopy journal September 2018

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