Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus

Guo, Chun-Jun; Sun, Wei-wen; Bruno, Kenneth S.; Wang, Clay C.

doi:10.1021/ol502242a

Title: Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus

Journal Article · Mon Sep 29 00:00:00 EDT 2014 · Organic Letters

DOI:https://doi.org/10.1021/ol502242a· OSTI ID:1167618

Guo, Chun-Jun ^[1]; Sun, Wei-wen ^[1]; Bruno, Kenneth S. ^[2]; Wang, Clay C. ^[3]

Univ. of Southern California, Los Angeles, CA (United States). Dept. of Pharmacology and Pharmaceutical Sciences
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Univ. of Southern California, Los Angeles, CA (United States). Dept. of Pharmacology and Pharmaceutical Sciences; Univ. of Southern California, Los Angeles, CA (United States). Dept. of Chemistry

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, in combined with bioinformatic analyses, allowed us to propose a biosynthetic pathway for terreic acid. Lastly, defining the pathway and the genes involved will facilitate the engineering of this molecule with interesting antimicrobial and antitumor bioactivities.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Sustainable Transportation Office. Bioenergy Technologies Office

Grant/Contract Number:: AC05-76RL01830; PO1GM084077; 1136903

OSTI ID:: 1167618

Report Number(s):: PNNL-SA-102991; BM0101020

Journal Information:: Organic Letters, Vol. 16, Issue 20; ISSN 1523-7060

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 24 works

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Discovery of McrA, a master regulator of Aspergillus secondary metabolism: McrA regulates Aspergillus secondary metabolism Oakley, C. Elizabeth; Ahuja, Manmeet; Sun, Wei-Wen Molecular Microbiology, Vol. 103, Issue 2 https://doi.org/10.1111/mmi.13562	journal	November 2016
Bacillus subtilis PTA-271 Counteracts Botryosphaeria Dieback in Grapevine, Triggering Immune Responses and Detoxification of Fungal Phytotoxins Trotel-Aziz, Patricia; Abou-Mansour, Eliane; Courteaux, Barbara Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00025	journal	January 2019
Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis Kong, Chuixing; Huang, Hezhou; Xue, Ying Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-20514-x	journal	February 2018
Chemodiversity in the genus Aspergillus Frisvad, Jens C.; Larsen, Thomas O. Applied Microbiology and Biotechnology, Vol. 99, Issue 19 https://doi.org/10.1007/s00253-015-6839-z	journal	August 2015
Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018) Romsdahl, Jillian; Wang, Clay C. C. MedChemComm, Vol. 10, Issue 6 https://doi.org/10.1039/c9md00054b	journal	January 2019
Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges Cheng, Cheng; MacIntyre, Lynsey; Abdelmohsen, Usama Ramadan PLOS ONE, Vol. 10, Issue 9 https://doi.org/10.1371/journal.pone.0138528	journal	September 2015
Secondary metabolism in Penicillium expansum : Emphasis on recent advances in patulin research Tannous, Joanna; Keller, Nancy P.; Atoui, Ali Critical Reviews in Food Science and Nutrition, Vol. 58, Issue 12 https://doi.org/10.1080/10408398.2017.1305945	journal	June 2017
Recent advances in genome mining of secondary metabolites in Aspergillus terreus Guo, Chun-Jun; Wang, Clay C. C. Frontiers in Microbiology, Vol. 5 https://doi.org/10.3389/fmicb.2014.00717	journal	December 2014
Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species Nielsen, Jens Christian; Grijseels, Sietske; Prigent, Sylvain Nature Microbiology, Vol. 2, Issue 6 https://doi.org/10.1038/nmicrobiol.2017.44	journal	April 2017
Biosynthetic gene clusters and the evolution of fungal chemodiversity Rokas, Antonis; Mead, Matthew E.; Steenwyk, Jacob L. Natural Product Reports, Vol. 37, Issue 7 https://doi.org/10.1039/c9np00045c	journal	January 2020

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59 BASIC BIOLOGICAL SCIENCES
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