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Title: Triazine-Based Tool Box for Developing Peptidic PET Imaging Probes: Syntheses, Microfluidic Radiolabeling, and Structure–Activity Evaluation

Journal Article · · Bioconjugate Chemistry
DOI:https://doi.org/10.1021/bc500034n· OSTI ID:1158700
 [1];  [1];  [2];  [2];  [3];  [3];  [2];  [3];  [1]
  1. Radiological Sciences Division, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, United States
  2. Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Boulevard, St. Louis, Missouri 63108, United States
  3. Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States
+ Show Author Affiliations

Sponsoring Organization:
USDOE
Grant/Contract Number:
FG02-07ER46453; FG02-07ER46471
OSTI ID:
1158700
Journal Information:
Bioconjugate Chemistry, Journal Name: Bioconjugate Chemistry Vol. 25 Journal Issue: 4; ISSN 1043-1802
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 19 works
Citation information provided by
Web of Science

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MicroPET and Autoradiographic Imaging of Breast Cancer α v -Integrin Expression Using 18 F- and 64 Cu-Labeled RGD Peptide journal January 2004
Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide journal January 2007
Radiolabeled Cyclic RGD Peptides as Integrin α v β 3 -Targeted Radiotracers: Maximizing Binding Affinity via Bivalency journal August 2009
Chaotic Mixer for Microchannels journal January 2002
Angiogenesis and metastasis journal December 1996
Novel 64 Cu- and 68 Ga-Labeled RGD Conjugates Show Improved PET Imaging of α ν β 3 Integrin Expression and Facile Radiosynthesis journal July 2011
Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes journal January 2007
PET imaging of αvβ3 integrin expression in tumours with 68Ga-labelled mono-, di- and tetrameric RGD peptides journal September 2010
A Novel Solid Lipid Nanoparticle Formulation for Active Targeting to Tumor α v β 3 Integrin Receptors Reveals Cyclic RGD as A Double-Edged Sword journal July 2012
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Refolding Foldamers: Triazene-Arylene Oligomers That Change Shape with Chemical Stimuli journal September 2007
Conformation/activity studies of rationally designed potent anti-adhesive RGD peptides journal December 1992
Role of integrins in angiogenesis journal December 1996
An efficient chemical approach to bispecific antibodies and antibodies of high valency journal July 2009
Click Chemistry for 18 F-Labeling of RGD Peptides and microPET Imaging of Tumor Integrin α v β 3 Expression journal November 2007
Versatile Conjugation of Octreotide to Dendrimers by Cycloaddition (“Click”) Chemistry to Yield High-Affinity Multivalent Cyclic Peptide Dendrimers journal June 2009
Improving Tumor-Targeting Capability and Pharmacokinetics of 99m Tc-Labeled Cyclic RGD Dimers with PEG 4 Linkers journal December 2008
Arg-Gly-Asp constrained within cyclic pentapoptides Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1 journal October 1991
Improving Tumor Uptake and Excretion Kinetics of 99 m Tc-Labeled Cyclic Arginine-Glycine-Aspartic (RGD) Dimers with Triglycine Linkers journal December 2008
64Cu-Labeled Tetrameric and Octameric RGD Peptides for Small-Animal PET of Tumor  v 3 Integrin Expression journal July 2007
Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease journal May 2010
Gadolinium MRI Contrast Agents Based on Triazine Dendrimers: Relaxivity and In Vivo Pharmacokinetics journal October 2012
Linker Effects on Biological Properties of 111 In-Labeled DTPA Conjugates of a Cyclic RGDfK Dimer journal December 2007
Improving Tumor Uptake and Pharmacokinetics of 64 Cu-Labeled Cyclic RGD Peptide Dimers with Gly 3 and PEG 4 Linkers journal March 2009
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes journal July 2002
99m Tc-Galacto-RGD 2 : A Novel 99m Tc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging journal August 2013
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Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine journal January 2010
Peptidotriazoles on Solid Phase  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides journal May 2002
Pharmacokinetic Properties of Peptidic Radiopharmaceuticals: Reduced Uptake of (EH) 3 -Conjugates in Important Organs journal June 2013
An improved synthesis of a selective αvβ3-integrin antagonist cyclo(-RGDfK-) journal August 2000
Triazine dendrimers as drug delivery systems: From synthesis to therapy journal June 2012
Liver uptake of radiolabeled targeting proteins and peptides: considerations for targeting peptide conjugate design journal November 2012
68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice journal July 2009
Structural and Functional Aspects of RGD-Containing Cyclic Pentapeptides as Highly Potent and Selective Integrin α V β 3 Antagonists journal January 1996

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