Kinetics of the lamellar gel-fluid transition in phosphatidylcholine membranes in the presence of sugars

Journal Article · Wed Sep 24 04:00:00 EDT 2014 · Chemistry and Physics of Lipids

DOI:https://doi.org/10.1016/j.chemphyslip.2009.12.001· OSTI ID:1158409

Lenné, Thomas; Garvey, Christopher J.; Koster, Karen L.; Bryant, Gary ^[1]

---

1. ANSTO

Phase diagrams are presented for dipalmitoylphosphatidylcholine (DPPC) in the presence of sugars (sucrose) over a wide range of relative humidities (RHs). The phase information presented here, determined by small angle X-ray scattering (SAXS), is shown to be consistent with previous results achieved by differential scanning calorimetry (DSC). Both techniques show a significant effect of sucrose concentration on the phase behaviour of this phospholipid bilayer. An experimental investigation into the effect of sugars on the kinetic behaviour of the gel to fluid transition is also presented showing that increasing the sugar content appears to slightly increase the rate at which the transition occurs.

• Research Organization: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
• Sponsoring Organization: FOREIGN
• OSTI ID: 1158409
• Journal Information: Chemistry and Physics of Lipids, Journal Name: Chemistry and Physics of Lipids Journal Issue: (2) ; 02, 2010 Vol. 163; ISSN 0009-3084
• Publisher: Elsevier
• Country of Publication: United States
• Language: ENGLISH