Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

Trivillin, V. A.; Garabalino, M. A.; Colombo, L. L.; González, S. J.; Farías, R. O.; Monti Hughes, A.; Pozzi, E. C.C.; Bortolussi, S.; Altieri, S.; Itoiz, M. E.; Aromando, R. F.; Nigg, D. W.; Schwint, A. E.

doi:10.1016/j.apradiso.2013.11.115

Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

Journal Article · Sun Jun 01 04:00:00 EDT 2014 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2013.11.115· OSTI ID:1156920

Trivillin, V. A.; Garabalino, M. A.; Colombo, L. L.; González, S. J.; Farías, R. O.; Monti Hughes, A.; Pozzi, E. C.C.; Bortolussi, S.; Altieri, S.; Itoiz, M. E.; Aromando, R. F.; Nigg, D. W.; Schwint, A. E.

BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.

Research Organization:: Idaho National Laboratory (INL)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC07-05ID14517

OSTI ID:: 1156920

Report Number(s):: INL/JOU-14-33083

Journal Information:: Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Vol. 88; ISSN 0969-8043

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

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Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

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