Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays

Bajwa, Navdeep K; Maldonado, Carlos J.; Thundat, Thomas George; Passian, Ali

doi:10.1063/1.4869636

Title: Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays

Journal Article · Mon Mar 24 00:00:00 EDT 2014 · AIP Advances

DOI:https://doi.org/10.1063/1.4869636· OSTI ID:1133550

Bajwa, Navdeep K ^[1]; Maldonado, Carlos J. ^[2]; Thundat, Thomas George ^[3]; Passian, Ali ^[4]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
David Grant USAF Medical Center, CA (United States)
Univ. of Alberta, Edmonton, AB (Canada)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)

The effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We also demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1133550

Journal Information:: AIP Advances, Vol. 4, Issue 3; ISSN 2158-3226

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 11 works

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A Review on Surface Stress-Based Miniaturized Piezoresistive SU-8 Polymeric Cantilever Sensors Mathew, Ribu; Ravi Sankar, A. Nano-Micro Letters, Vol. 10, Issue 2 https://doi.org/10.1007/s40820-018-0189-1	journal	February 2018
Optimization of a nano-cantilever biosensor for reduced self-heating effects and improved performance metrics Mathew, Ribu; Ravi Sankar, A. Journal of Micromechanics and Microengineering, Vol. 28, Issue 8 https://doi.org/10.1088/1361-6439/aabeaf	journal	May 2018
Influence of surface layer properties on the thermo-electro-mechanical characteristics of a MEMS/NEMS piezoresistive cantilever surface stress sensor Mathew, Ribu; Ravi Sankar, A. Materials Research Express, Vol. 6, Issue 8 https://doi.org/10.1088/2053-1591/ab1c18	journal	May 2019
A High-Performance Optoelectronic Sensor Device for Nitrate Nitrogen in Recirculating Aquaculture Systems Wang, Cong; Li, Zhen; Pan, Zhongli Sensors, Vol. 18, Issue 10 https://doi.org/10.3390/s18103382	journal	October 2018
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