Luminescent macrocyclic lanthanide complexes

Raymond, Kenneth N; Corneillie, Todd M; Xu, Jide

Title: Luminescent macrocyclic lanthanide complexes

Patent · Tue May 20 00:00:00 EDT 2014

OSTI ID:1132073

Raymond, Kenneth N; Corneillie, Todd M; Xu, Jide

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,729,258

Application Number:: 13/460,120

OSTI ID:: 1132073

Resource Relation:: Patent File Date: 2012 Apr 30

Country of Publication:: United States

Language:: English

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Cited By (2)

Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides Raymond, Kenneth N.; Xu, Jide; Moore, Evan G. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9556122 US Patent Document 9,556,122	patent	January 2017
Macrocyclic HOPO chelators Butlin, Nathaniel G.; Raymond, Kenneth N.; Xu, Jide https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9273059 US Patent Document 9,273,059	patent	March 2016

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