skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1

Patent ·
OSTI ID:1131020

It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-000R22725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
8,722,625
Application Number:
12/284,667
OSTI ID:
1131020
Country of Publication:
United States
Language:
English

References (33)

Nell peptide expression systems and bone formation activity of nell peptide patent-application December 2006
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects journal March 2006
Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide patent-application September 2011
Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats journal December 1996
Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 journal January 2002
Cell-Based Approaches for Cardiac Repair journal October 2006
Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts journal March 2007
The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
  • Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
  • The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261 https://doi.org/10.1086/421527
journal June 2004
Nfatc2 is a primary response gene of nell-1 regulating chondrogenesis in ATDC5 cells journal May 2011
Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1 patent March 2011
Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors journal January 2001
Bone marrow cells for cardiac regeneration and repair: current status and issues journal July 2006
The osteoinductive properties of Nell-1 in a rat spinal fusion model journal January 2007
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene journal August 2007
Effect of Nell-1 Delivery on Chondrocyte Proliferation and Cartilaginous Extracellular Matrix Deposition journal May 2010
The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage journal April 1999
Composition for cartilage patent-application June 2007
Nell-1 induced bone formation within the distracted intermaxillary suture journal January 2006
NELL-1 enhanced bone mineralization patent May 2006
Nell-1 enhanced bone mineralization patent-application May 2006
Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development journal May 2006
Cranial and vertebral defects associated with loss-of-function of Nell patent-application March 2006
A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation journal October 2007
Human NELL-1 Expressed in Unilateral Coronal Synostosis journal January 1999
NELL-1 enhanced bone mineralization patent-application October 2006
Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2 journal November 1999
From cardiac repair to cardiac regeneration – ready to translate? journal August 2006
Growth Factor Enhancement of Cardiac Regeneration journal January 2006
Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C journal November 1999
Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development journal December 2003
Adenovirus vectors encoding brain natriuretic peptide patent-application February 2006
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice journal June 2001
Nell-1-Induced Bone Regeneration in Calvarial Defects journal September 2006

Similar Records

CHARACTERIZING THE ROLE OF THE NELL1 GENE IN CARDIOVASCULAR DEVELOPMENT
Journal Article · Mon Jan 01 00:00:00 EST 2007 · Journal of Undergraduate Research · OSTI ID:1131020

Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1
Patent · Tue Mar 20 00:00:00 EDT 2018 · OSTI ID:1131020

Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1
Patent · Tue Mar 22 00:00:00 EDT 2011 · OSTI ID:1131020

Related Subjects