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Title: Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase

Journal Article · · Biochemistry
DOI:https://doi.org/10.1021/bi201484k· OSTI ID:1123329
 [1];  [1];  [1];  [1];  [1]
  1. Chemistry, ‡Center for Environmental Health Sciences, §Biological Engineering, ∥Biology, ⊥Koch Institute for Integrative Cancer Research, and @Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI ID:
1123329
Journal Information:
Biochemistry, Journal Name: Biochemistry Vol. 51 Journal Issue: 1; ISSN 0006-2960
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 22 works
Citation information provided by
Web of Science

References (33)

Hopping Enables a DNA Repair Glycosylase To Search Both Strands and Bypass a Bound Protein journal March 2010
The one-dimensional diffusion coefficient of proteins absorbed on DNA journal May 1979
Recognition and Processing of a New Repertoire of DNA Substrates by Human 3-Methyladenine DNA Glycosylase (AAG) journal March 2009
Electrostatics of nanosystems: Application to microtubules and the ribosome journal August 2001
Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair journal May 1998
Structure of a DNA Glycosylase Searching for Lesions journal February 2006
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory journal November 1981
Heterogeneous repair of N -methylpurines at the nucleotide level in normal human cells 1 1Edited by M. Yahiv journal November 1998
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. journal December 1996
Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNA journal April 2011
Repair of Endogenous DNA Damage journal January 2000
Nonspecifically bound proteins spin while diffusing along DNA journal November 2009
Human Alkyladenine DNA Glycosylase Employs a Processive Search for DNA Damage journal October 2008
Long-distance lateral diffusion of human Rad51 on double-stranded DNA journal January 2006
Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation journal October 2009
PROCHECK: a program to check the stereochemical quality of protein structures journal April 1993
Kinetic Mechanism for the Flipping and Excision of 1, N 6 -Ethenoadenine by Human Alkyladenine DNA Glycosylase journal November 2009
Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG journal December 2000
Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase journal March 2010
Human Alkyladenine DNA Glycosylase Uses Acid−Base Catalysis for Selective Excision of Damaged Purines journal October 2003
Structure of Escherichia coli AlkA in Complex with Undamaged DNA journal September 2010
Dissecting the Broad Substrate Specificity of Human 3-Methyladenine-DNA Glycosylase journal December 2003
Superconducting Single Crystals of Tl2Ba2CaCu2O8 and YBa2Cu4O8: Crystal Structures in the Vicinity of Tc journal November 1998
Detection of Damaged DNA Bases by DNA Glycosylase Enzymes journal June 2010
Hijacking of the Human Alkyl-N-purine-DNA Glycosylase by 3,N4-Ethenocytosine, a Lipid Peroxidation-induced DNA Adduct journal April 2004
Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA journal October 1998
Substitution of Active Site Tyrosines with Tryptophan Alters the Free Energy for Nucleotide Flipping by Human Alkyladenine DNA Glycosylase journal February 2011
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA journal April 2006
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA journal February 2000
Instability and decay of the primary structure of DNA journal April 1993
DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA journal February 2000
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Phaser crystallographic software journal July 2007

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