Regulation and Function of Adult Neurogenesis. From Genes to Cognition

Aimone, J. B.; Li, Y.; Lee, S. W.; Clemenson, G. D.; Deng, W.; Gage, F. H.

doi:10.1152/physrev.00004.2014

Regulation and Function of Adult Neurogenesis. From Genes to Cognition

Journal Article · Wed Oct 01 00:00:00 EDT 2014 · Physiological Reviews

DOI:https://doi.org/10.1152/physrev.00004.2014· OSTI ID:1114606

Aimone, J. B. ^[1]; Li, Y. ^[1]; Lee, S. W. ^[1]; Clemenson, G. D. ^[1]; Deng, W. ^[1]; Gage, F. H. ^[1]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Salt Inst. for Biological Studies, La Jolla, CA (United States)

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1114606

Report Number(s):: SAND--2013-8756J; 476985

Journal Information:: Physiological Reviews, Journal Name: Physiological Reviews Journal Issue: 4 Vol. 94; ISSN 0031-9333

Publisher:: American Physiological SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Functions of adiponectin signaling in regulating neural plasticity and its application as the therapeutic target to neurological and psychiatric diseases Sun, Li-na; Liu, Xiao-li Reviews in the Neurosciences, Vol. 30, Issue 5 https://doi.org/10.1515/revneuro-2018-0062	journal	July 2019
Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease Parodi-Rullán, Rebecca; Sone, Je Yeong; Fossati, Silvia Journal of Alzheimer's Disease, Vol. 72, Issue 4 https://doi.org/10.3233/jad-190357	journal	December 2019
Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health Navarro-Sanchis, Cristina; Brock, Olivier; Winsky-Sommerer, Raphaelle Frontiers in Neural Circuits, Vol. 11 https://doi.org/10.3389/fncir.2017.00074	journal	October 2017

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