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Detectability of Neuronal Currents in Human Brain with Magnetic Resonance Spectroscopy.

Technical Report ·
DOI:https://doi.org/10.2172/1113876· OSTI ID:1113876
 [1];  [1];  [1];  [2];  [3];  [2];  [4];  [1]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  2. Mind Research Network, Albuquerque, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States)
  3. Mind Research Network, Albuquerque, NM (United States)
  4. Mind Research Network, Albuquerque, NM (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
+ Show Author Affiliations
Magnetic resonance spectroscopy has been used in a high-risk, high-payoff search for neuronal current (NC) signals in the free induction decay (FID) data from the visual cortex of human subjects during visual stimulation. If successful, this approach could make possible the detection of neuronal currents in the brain at high spatial and temporal resolution. Our initial experiments indicated the presence of a statistically significant change in the FID containing the NC relative to FIDs with the NC absent, and this signal was consistent with the presence of NC. Unfortunately, two follow-on experiments were not able to confirm or replicate the positive findings of the first experiment. However, even if the result from the first experiment were evidence of NC in the FID, it is clear that its effect is so small, that a true NC imaging experiment would not be possible with the current instrumentation and experimental protocol used here.
Research Organization:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
DOE Contract Number:
AC04-94AL85000
OSTI ID:
1113876
Report Number(s):
SAND2012--8198; 473109
Country of Publication:
United States
Language:
English

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62 RADIOLOGY AND NUCLEAR MEDICINE