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Title: Laser heating of aqueous samples on a micro-optical-electro-mechanical system

Patent ·
OSTI ID:1110817
;

A system of heating a sample on a microchip includes the steps of providing a microchannel flow channel in the microchip; positioning the sample within the microchannel flow channel, providing a laser that directs a laser beam onto the sample for heating the sample; providing the microchannel flow channel with a wall section that receives the laser beam and enables the laser beam to pass through wall section of the microchannel flow channel without being appreciably heated by the laser beam; and providing a carrier fluid in the microchannel flow channel that moves the sample in the microchannel flow channel wherein the carrier fluid is not appreciably heated by the laser beam.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA); The Board of Regents, The University of California (Oakland, CA)
Patent Number(s):
8,610,032
Application Number:
13/732,949
OSTI ID:
1110817
Country of Publication:
United States
Language:
English

References (11)

Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser patent December 2010
Nucleic acid amplification using microfluidic devices patent-application October 2005
Real-time PCR of targets on a micro-array patent August 2012
Array assay devices and methods of using the same patent May 2007
Method and device for biochemical detection and analysis of subcellular compartments from a single cell patent-application March 2005
Monodispersed microfluidic droplet generation by shear focusing microfluidic device journal March 2006
Non-contact radiant heating and temperature sensing device for a chemical reaction chamber patent February 2007
Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture patent-application July 2008
Chip-based isothermal amplification devices and methods patent-application November 2002
Single molecule amplification and detection of DNA length patent-application February 2005
Non-contact radiant heating and temperature sensing device for a chemical reaction chamber patent December 2004

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