Evidence for linkage disequilibrium in chromosome 13-linked Duchenne-like muscular dystrophy
Journal Article
·
· American Journal of Human Genetics
OSTI ID:110963
- Duke Univ. Medical Center, Durham, NC (United States); and others
Duchenne-like muscular dystrophy (DLMD) is an autosomal recessive Limb Girdle muscular dystrophy (LGMD2C) characterized by late age of onset, proximal muscle weakness leading to disability, high creatine kinase values, normal intelligence and normal dystrophin in muscle biopsy. We have shown previously that three DLMD families from Tunisia are linked to chromosome 13q12. To further localize the LGMD2C gene, we have investigated seven additional families (119 individuals). Both genotyping and two-point linkage analysis were performed as described elsewhere. 7 refs., 1 fig., 1 tab.
- OSTI ID:
- 110963
- Journal Information:
- American Journal of Human Genetics, Vol. 57, Issue 3; Other Information: PBD: Sep 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mild and severe muscular dystrophy caused by a single {gamma}-sarcoglycan mutation
Possible influences on the expression of X chromosome-linked dystrophin abnormalities by heterozygosity for autosomal recessive Fukuyama congenital muscular dystrophy
Detection of new paternal dystrophin gene mutations in isolated cases of dystrophinopathy in females
Journal Article
·
Fri Nov 01 00:00:00 EST 1996
· American Journal of Human Genetics
·
OSTI ID:110963
Possible influences on the expression of X chromosome-linked dystrophin abnormalities by heterozygosity for autosomal recessive Fukuyama congenital muscular dystrophy
Journal Article
·
Wed Jan 15 00:00:00 EST 1992
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:110963
+4 more
Detection of new paternal dystrophin gene mutations in isolated cases of dystrophinopathy in females
Journal Article
·
Wed Jun 01 00:00:00 EDT 1994
· American Journal of Human Genetics; (United States)
·
OSTI ID:110963
+7 more