The course of lysine hydroxylation during collagen biosynthesis
Conference
·
OSTI ID:1098267
Lysine is the obligatory precursor of the 5-hydroxylysine of collagen in rats and presumably in other species. Hydroxylysine, either fed or injected, is not incorporated into collagen. It seems probably that lysine is hydroxyated as a bound amino acid during the course of collagen synthesis. The biochemical mechanism of the introduction of the hydroxyl group onto the number 5 carbon atom of lysine has been studied recently, using lysine labeled with tritium in specific positions.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Organization:
- US Atomic Energy Commission (AEC)
- DOE Contract Number:
- AT(30-2)-GEN-16
- OSTI ID:
- 1098267
- Report Number(s):
- BNL--9476; CONF-650823--1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Biosynthesis of collagen crosslinks. III. In vivo labeling and stability of lung collagen in rats with bleomycin-induced pulmonary fibrosis
(4,5-/sup 3/H)lysine:(/sup 14/C)lysine dual-label method to measure lysine hydroxylation in collagen
Pyridinium cross-links in heritable disorders of collagen
Journal Article
·
Tue Aug 01 00:00:00 EDT 1989
· American Journal of Respiratory Cell and Molecular Biology; (USA)
·
OSTI ID:6945645
(4,5-/sup 3/H)lysine:(/sup 14/C)lysine dual-label method to measure lysine hydroxylation in collagen
Journal Article
·
Wed Oct 01 00:00:00 EDT 1986
· Anal. Biochem.; (United States)
·
OSTI ID:6937284
Pyridinium cross-links in heritable disorders of collagen
Journal Article
·
Thu Nov 30 23:00:00 EST 1995
· American Journal of Human Genetics
·
OSTI ID:186223