Solvent effects on proteinfast dynamics: iplications for biopreservation

Journal Article · Mon Dec 31 23:00:00 EST 2012 · Soft Matter

DOI:https://doi.org/10.1039/c3sm50492a· OSTI ID:1096355

Garcia Sakai, V ^[1]; Khodadadi, S ^[2]; Cicerone, Marcus T ^[3]; Curtis, J. E. ^[4]; Sokolov, Alexei P ^[5]; Roh, J H ^[6]

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1. University of Maryland and NIST
2. University of Akron
3. National Institute of Standards and Technology, Gaithersburg MD
4. National Institute of Standards and Technology (NIST), Gaithersburg, MD
5. ORNL
6. University of Maryland

In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.

• Research Organization: Oak Ridge National Laboratory (ORNL)
• Sponsoring Organization: SC USDOE - Office of Science (SC)
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 1096355
• Journal Information: Soft Matter, Journal Name: Soft Matter Journal Issue: 22 Vol. 9; ISSN 1744-683X
• Country of Publication: United States
• Language: English