Comparative Developmental Toxicity of Environmentally Relevant Oxygenated PAHs

Journal Article · Sun Sep 01 00:00:00 EDT 2013 · Toxicology and Applied Pharmacology, 271(2):266-275

DOI:https://doi.org/10.1016/j.taap.2013.05.006· OSTI ID:1094916

Knecht, Andrea; Goodale, Britton; Truong, Lisa; Simonich, Michael; Swanson, Annika; Matzke, Melissa M.; Anderson, Kim A.; Waters, Katrina M.; Tanguay, Robert

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants in urban air, dust and in the soil of most industrial coal gassification, coal burning, coke production and wood preservation sites (Howsam and Jones 1998). It is widely recognized that PAHs pose risks to human health,having been associated with increased risks of systemic inflammation (Delfino et al. 2010), cardiopulmonary mortality (Lee et al. 2011; Lewtas 2007) and lung cancer mortality (Grant 2009; Hoshuyama et al. 2006). The potential risks may be especially acute for the developing fetus and infant where PAH exposures have been linked to low birth weight, intrauterine growth retardation, in-utero mortality and lower intelligence (Dejmek et al. 1999; Dejmek et al. 2000; Perera et al. 1999; Perera et al. 2009; Perera et al. 2006; Perera et al. 1998; Wu et al. 2010). Despite the more than two decades of intensive study devoted to parent PAHs, they are only part of the hazard spectrum from PAH contamination.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1094916
• Report Number(s): PNNL-SA-91217; 600306000
• Journal Information: Toxicology and Applied Pharmacology, 271(2):266-275, Journal Name: Toxicology and Applied Pharmacology, 271(2):266-275
• Country of Publication: United States
• Language: English