Methods and compositions for targeting macromolecules into the nucleus

Chook, Yuh Min

Title: Methods and compositions for targeting macromolecules into the nucleus

Patent · Tue Jun 25 00:00:00 EDT 2013

OSTI ID:1086949

Chook, Yuh Min

The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-31-109-ENG-38

Assignee:: Board of Regents, The University of Texas System (Austin, TX)

Patent Number(s):: 8,470,976

Application Number:: 11/697,656

OSTI ID:: 1086949

Country of Publication:: United States

Language:: English

References (32)

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