Low dose radiation hypersensitivity and clustered DNA damages in human fibroblasts exposed to low dose and dose rate protons or 137CS y-rays

Conference · Tue May 14 04:00:00 EDT 2013

OSTI ID:1079889

Bennett, P. V.; Keszenman, D. J.; Johnson, A. M.; Sutherland, B. M.; Wilson, P. F.

Effective radioprotection for human space travelers hinges upon understanding the individual properties of charged particles. A significant fraction of particle radiation astronauts will encounter in space exploratory missions will come from high energy protons in galactic cosmic radiation (GCR) and/or possible exposures to lower energy proton flux from solar particle events (SPEs). These potential exposures present major concerns for NASA and others, in planning and executing long term space exploratory missions. We recently reported cell survival and transformation (acquisition of anchorage-independent growth in soft agar) frequencies in apparently normal NFF-28 primary human fibroblasts exposed to 0-30 cGy of 50MeV, 100MeV (SPE-like), or 1000 MeV (GCR-like) monoenergetic protons. These were modeled after 1989 SPE energies at an SPE-like low dose-rate (LDR) of 1.65 cGy/min or high dose rate (HDR) of 33.3 cGy/min delivered at the NASA Space Radiation Laboratory (NSRL) at BNL.

• Research Organization: Brookhaven National Laboratory (BNL) NASA Space Radiation Laboratory
• Sponsoring Organization: USDOE SC OFFICE OF BIOLOGICAL & ENVIRONMENTAL RESEARCH
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 1079889
• Report Number(s): BNL--100619-2013-CP; KP1602020
• Country of Publication: United States
• Language: English

Related Subjects

61 RADIATION PROTECTION AND DOSIMETRY
Cesium-137
DNA
NASA (National Aeronautics and Space Administration)
fibroblasts
nasa space radiation laboratory