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Study of the structure and function of a novel bacterial virulence factor isolated from Francisella tularensis

Technical Report ·
DOI:https://doi.org/10.2172/1079665· OSTI ID:1079665
 [1];  [1];  [1];  [1]
  1. Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
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During my internship at Lawrence Livermore National Laboratory (LLNL), I studied a novel virulence factor of the potential bioterrorism agent, Francisella tularensis. This bacterium is a facultative intracellular pathogen with a broad host range, and is known to be the causative agent of the zoonotic disease tularemia (1). F. tularensis is highly infectious, requiring only 1 to 10 bacteria to cause severe disease (2). Due to its high rate of infectivity, F. tularensis has potential use as a bioterrorism agent. As a result, it has been categorized as a class A biothreat pathogen by the Centers for Disease Control and Prevention (3).

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
US Department of Homeland Security (DHS); USDOE Laboratory Directed Research and Development (LDRD) Program
DOE Contract Number:
W-7405-ENG-48; AC05-06OR23100; AC52-07NA27344
OSTI ID:
1079665
Report Number(s):
LLNL--TR-572332
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES