Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer

Hu, Zhi; Kuo, Wen-Lin; Neve, Richard M; Gray, Joe W

Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer

Patent · Tue Jun 12 04:00:00 EDT 2012

OSTI ID:1055690

Hu, Zhi ^[1]; Kuo, Wen-Lin ^[2]; Neve, Richard M ^[3]; Gray, Joe W ^[4]

El Cerrito, CA
San Ramon, CA
San Mateo, CA
San Francisco, CA

Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

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Research Organization:: University of California (Oakland, CA)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,198,254

Application Number:: 12/412,304

OSTI ID:: 1055690

Country of Publication:: United States

Language:: English

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Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer

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