Structure determination of enterovirus 71

Journal Article · Wed Feb 20 00:00:00 EST 2013 · Acta Crystallogr. D

DOI:https://doi.org/10.1107/S0907444912025772· OSTI ID:1050749

Plevka, Pavel; Perera, Rushika; Cardosa, Jane; Kuhn, Richard J; Rossmann, Michael G ^[1]

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1. Purdue

Enterovirus 71 is a picornavirus that causes hand, foot and mouth disease but may induce fatal neurological illness in infants and young children. Enterovirus 71 crystallized in a body-centered orthorhombic space group with two particles in general orientations in the crystallographic asymmetric unit. Determination of the particle orientations required that the locked rotation function excluded the twofold symmetry axes from the set of icosahedral symmetry operators. This avoided the occurrence of misleading high rotation-function values produced by the alignment of icosahedral and crystallographic twofold axes. Once the orientations and positions of the particles had been established, the structure was solved by molecular replacement and phase extension.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: National Institutes of Health (NIH)
• OSTI ID: 1050749
• Journal Information: Acta Crystallogr. D, Vol. 68, Issue (9) ; 09, 2012
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
CHILDREN
DISEASES
FUNCTIONS
INFANTS
ORAL CAVITY
PARTICLES
ROTATION
SPACE GROUPS
SYMMETRY
VIRUSES