THE ATTENUATED RADON TRANSFORM: APPLICATION TO SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY IN THE PRESENCE OF A VARIABLE ATTENUATING MEDIUM
Journal Article
·
· SIAM Journal on Applied Mathematics
OSTI ID:1048252
The properties of the attenuated Radon transform and its application to single-photon emission computed tomography (ECT) are analyzed in detail. In nuclear medicine and biological research, the objective of ECT is to describe quantitatively the position and strengths of internal sources of injected radiopharmaceuticals and radionuclides where the attenuation between the sources and detector is unknown. The problem is mathematically and practically quite different from well-known methods in transmission computed tomography (TCT) where only the attenuation is unknown. A mathematical structure using function theory and the theory of linear operators on Hilbert spaces is developed to better understand the spectral properties of the attenuated Radon transform. The continuous attenuated Radon transform is reduced to a matrix operator for discrete angular and lateral sampling, and the reconstruction problem reduces to a system of linear equations. For variable attenuation coefficients frequently found in imaging internal organs, the numerical methods developed in this paper involve iterative techniques of performing the generalized inverse. Its application to nuclear medicine is demonstrated by reconstructions of transverse sections of the brain, heart, and liver.
- Research Organization:
- Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
- Sponsoring Organization:
- Physical Biosciences Division
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1048252
- Report Number(s):
- LBL-10276
- Journal Information:
- SIAM Journal on Applied Mathematics, Journal Name: SIAM Journal on Applied Mathematics
- Country of Publication:
- United States
- Language:
- English
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