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Title: A new chapter in the transcription SAGA

Abstract

Eukaryotic transcriptional coactivators are multi-subunit complexes that both modify chromatin and recognize histone modifications. Until recently, structural information on these large complexes has been limited to isolated enzymatic domains or chromatin-binding motifs. This review summarizes recent structural studies of the SAGA coactivator complex that have greatly advanced our understanding of the interplay between its different subunits. The structure of the four-protein SAGA deubiquitinating module has provided a first glimpse of the larger organization of a coactivator complex, and illustrates how interdependent subunits interact with each other to form an active and functional enzyme complex. In addition, structures of the histone binding domains of ATXN7 and Sgf29 shed light on the interactions with chromatin that help recruit the SAGA complex.

Authors:
;  [1]
  1. (HHMI)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
UNIVERSITYHHMI
OSTI Identifier:
1047303
Resource Type:
Journal Article
Journal Name:
Curr. Opin. Struct. Biol.
Additional Journal Information:
Journal Volume: 21; Journal Issue: (6) ; 12, 2011
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; CHROMATIN; COMPLEXES; ENZYMES; HISTONES; INTERACTIONS; MODIFICATIONS; TRANSCRIPTION

Citation Formats

Samara, Nadine L., and Wolberger, Cynthia. A new chapter in the transcription SAGA. United States: N. p., 2012. Web. doi:10.1016/j.sbi.2011.09.004.
Samara, Nadine L., & Wolberger, Cynthia. A new chapter in the transcription SAGA. United States. doi:10.1016/j.sbi.2011.09.004.
Samara, Nadine L., and Wolberger, Cynthia. Mon . "A new chapter in the transcription SAGA". United States. doi:10.1016/j.sbi.2011.09.004.
@article{osti_1047303,
title = {A new chapter in the transcription SAGA},
author = {Samara, Nadine L. and Wolberger, Cynthia},
abstractNote = {Eukaryotic transcriptional coactivators are multi-subunit complexes that both modify chromatin and recognize histone modifications. Until recently, structural information on these large complexes has been limited to isolated enzymatic domains or chromatin-binding motifs. This review summarizes recent structural studies of the SAGA coactivator complex that have greatly advanced our understanding of the interplay between its different subunits. The structure of the four-protein SAGA deubiquitinating module has provided a first glimpse of the larger organization of a coactivator complex, and illustrates how interdependent subunits interact with each other to form an active and functional enzyme complex. In addition, structures of the histone binding domains of ATXN7 and Sgf29 shed light on the interactions with chromatin that help recruit the SAGA complex.},
doi = {10.1016/j.sbi.2011.09.004},
journal = {Curr. Opin. Struct. Biol.},
number = (6) ; 12, 2011,
volume = 21,
place = {United States},
year = {2012},
month = {11}
}