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Title: Developing Research Capabilities in Energy Biosciences: Design principles of photosynthetic biofuel production.

Abstract

The current fossil fuel-based energy infrastructure is not sustainable. Solar radiation is a plausible alternative, but realizing it as such will require significant technological advances in the ability to harvest light energy and convert it into suitable fuels. The biological system of photosynthesis can carry out these reactions, and in principle could be engineered using the tools of synthetic biology. One desirable implementation would be to rewire the reactions of a photosynthetic bacterium to direct the energy harvested from solar radiation into the synthesis of the biofuel H2. Proposed here is a series of experiments to lay the basic science groundwork for such an attempt. The goal is to elucidate the transcriptional network of photosynthesis using a novel driver-reporter screen, evolve more robust hydrogenases for improved catalysis, and to test the ability of the photosynthetic machinery to directly produce H2 in vivo. The results of these experiments will have broad implications for the understanding of photosynthesis, enzyme function, and the engineering of biological systems for sustainable energy production. The ultimate impact could be a fundamental transformation of the world's energy economy.

Authors:
;
Publication Date:
Research Org.:
Life Sciences Research Foundation
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1044608
Report Number(s):
DOE/ER/15978
LSRF Final Report
DOE Contract Number:  
FG02-08ER15978
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; photosynthesis, enzyme function, metabloism, protein structure and function, signal transduction, development and differentiation

Citation Formats

Donald D. Brown, and David Savage. Developing Research Capabilities in Energy Biosciences: Design principles of photosynthetic biofuel production.. United States: N. p., 2012. Web. doi:10.2172/1044608.
Donald D. Brown, & David Savage. Developing Research Capabilities in Energy Biosciences: Design principles of photosynthetic biofuel production.. United States. doi:10.2172/1044608.
Donald D. Brown, and David Savage. Sat . "Developing Research Capabilities in Energy Biosciences: Design principles of photosynthetic biofuel production.". United States. doi:10.2172/1044608. https://www.osti.gov/servlets/purl/1044608.
@article{osti_1044608,
title = {Developing Research Capabilities in Energy Biosciences: Design principles of photosynthetic biofuel production.},
author = {Donald D. Brown and David Savage},
abstractNote = {The current fossil fuel-based energy infrastructure is not sustainable. Solar radiation is a plausible alternative, but realizing it as such will require significant technological advances in the ability to harvest light energy and convert it into suitable fuels. The biological system of photosynthesis can carry out these reactions, and in principle could be engineered using the tools of synthetic biology. One desirable implementation would be to rewire the reactions of a photosynthetic bacterium to direct the energy harvested from solar radiation into the synthesis of the biofuel H2. Proposed here is a series of experiments to lay the basic science groundwork for such an attempt. The goal is to elucidate the transcriptional network of photosynthesis using a novel driver-reporter screen, evolve more robust hydrogenases for improved catalysis, and to test the ability of the photosynthetic machinery to directly produce H2 in vivo. The results of these experiments will have broad implications for the understanding of photosynthesis, enzyme function, and the engineering of biological systems for sustainable energy production. The ultimate impact could be a fundamental transformation of the world's energy economy.},
doi = {10.2172/1044608},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}