Beta Androstenediol Mitigates the Damage of 1 GeV/n Fe Ion Particle Radiation to the Hematopoietic System

Journal Article · Tue Sep 07 00:00:00 EDT 2010 · Cancer Biotherapy and Radiopharmaceuticals

OSTI ID:1043386

Loria, R; Guida, P; Loria, R; Beckman, M; Contaifer, D; Tamariz, F; Gibb, D; Thompson, L; Guida, P

Space exploration is associated with exposure to 1-3 Gy solar particle radiation and galactic cosmic radiation that could increase cancer rates. Effective nontoxic countermeasures to high linear energy transfer (LET) radiation exposure are highly desirable but currently not available. The aim was to determine whether a single subcutaneous injection of androstenediol ({Delta}(5) androsten-3{beta}, 17{beta}-diol [AED]) could mitigate and restore the mouse hematopoetic system from the radiation-mediated injury of 3 Gy whole-body high LET (56)Fe(26+) exposure. The findings show that postradiation AED treatment has an overall positive and significant beneficial effect to restore the levels of hematopoeitic elements (p < 0.001). Androstenediol treatment significantly increased monocyte levels at days 4, 7, and 14 and, similarly, increased red blood cell, hemoglobin, and platelet counts. Flow cytometry analysis 14 days after radiation and AED treatment demonstrated an increase (p < 0.05) in bone marrow cells counts. Ex vivo osteoclastogenesis studies show that AED treatment is necessary and advantageous for the development and restoration of osteoclastogenesis after radiation exposure. These findings clearly show that androstenediol functions as a countermeasure to remedy hematopoeitic injury mediated by high LET iron ion radiation. Presently, no other agent has been shown to have such properties.

• Research Organization: Brookhaven National Laboratory (BNL) NASA Space Radiation Laboratory
• Sponsoring Organization: National Cancer Institute (NCI)
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1043386
• Report Number(s): BNL-96991-2012-JA; 400409900; TRN: US201213%%336
• Journal Information: Cancer Biotherapy and Radiopharmaceuticals, Vol. 26, Issue 4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
BLOOD CELLS
BONE MARROW CELLS
COSMIC RADIATION
EXPLORATION
HEMATOPOIETIC SYSTEM
HEMOGLOBIN
IRON IONS
LET
MONOCYTES
NEOPLASMS
RADIATIONS
SOLAR PARTICLES
SUBCUTANEOUS INJECTION
androstenediol
bone marrow
high LET radiation
hematopoietic
osteoclastogenesis
radioprotector
nasa space radiation laboratory