Crystal structure of a group II intron in the pre-catalytic state
- Cornell
Group II introns are self-splicing catalytic RNAs that are thought to be ancestral to the spliceosome. Here we report the 3.65-{angstrom} crystal structure of the group II intron from Oceanobacillus iheyensis in the pre-catalytic state. The structure reveals the conformation of the 5' splice site in the catalytic core and represents the first structure of an intron prior to the first step of splicing.
- Research Organization:
- Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
- Sponsoring Organization:
- UNIVERSITYNIHHHMI
- OSTI ID:
- 1042495
- Journal Information:
- Nat. Struct. Mol. Biol., Journal Name: Nat. Struct. Mol. Biol. Journal Issue: (5) ; 05, 2012 Vol. 19; ISSN 1545-9993
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Crystal Structure of a Self-Spliced Group II Intron
Crystal Structure of a Self-Spliced Group ll Intron
Tertiary architecture of the Oceanobacillus iheyensis group II intron
Journal Article
·
Thu Apr 10 00:00:00 EDT 2008
· Science
·
OSTI ID:1006553
Crystal Structure of a Self-Spliced Group ll Intron
Journal Article
·
Mon Dec 31 23:00:00 EST 2007
· Science
·
OSTI ID:959859
Tertiary architecture of the Oceanobacillus iheyensis group II intron
Journal Article
·
Mon May 03 00:00:00 EDT 2010
· RNA
·
OSTI ID:1002324