Ferritin-Polymer Conjugates: Grafting Chemistry and Integration into Nanoscale Assemblies
Journal Article
·
· Advanced Functional Materials
OSTI ID:1042141
Controlled free radical polymerization chemistry is used to graft polymer chains to the corona of horse spleen ferritin (HSF) nanocages. Specifically, poly(methacryloyloxyethyl phosphorylcholine) (polyMPC) and poly(PEG methacrylate) (polyPEGMA) chains are grafted onto the nanocages by atom transfer radical polymerization (ATRP), in which the molecular weight of the polymer grafts is controlled by the monomer-to-initiator feed ratio. PolyMPC and polyPEGMA-grafted ferritin show a generally suppressed inclusion into diblock copolymer films relative to native ferritin, and the polymer coating is seen to mask the ferritin nanocages from antibody recognition. The solubility of polyPEGMA-coated ferritin in organic solvents enables its processing with polystyrene-block-poly(ethylene oxide) copolymers, and selective integration into the PEO domains of microphase-separated copolymer structures.
- Research Organization:
- BROOKHAVEN NATIONAL LABORATORY (BNL)
- Sponsoring Organization:
- USDOE SC OFFICE OF SCIENCE (SC)
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1042141
- Report Number(s):
- BNL--97819-2012-JA
- Journal Information:
- Advanced Functional Materials, Journal Name: Advanced Functional Materials Journal Issue: 20 Vol. 20; ISSN 1616-301X
- Country of Publication:
- United States
- Language:
- English
Similar Records
SYNTHESIS AND PROPERTIES OF THE GRAFTED COPOLYMERS POLY(METHYL METHACRYLATE)-POLYSTYRENE. II. FORMATION OF GRAFTED COPOLYMERS BY DIRECT IRRADIATION AND CHARACTERIZATION OF THE PRODUCTS OBTAINED BY LIGHT SCATTERING
Macroscopic lateral heterogeneity observed in a laterally mobile immiscible mixed polyelectrolyte-neutral polymer brush
Acrylic acid polymerization and its graft copolymerization to poly(ethylene oxide) by gamma rays
Journal Article
·
Fri Jun 01 00:00:00 EDT 1962
· Journal de Chimie Physique (France) Merged with Rev. Gen. Colloides to form J. Chim. Phys. Rev. Gen. Colloides
·
OSTI ID:4794133
Macroscopic lateral heterogeneity observed in a laterally mobile immiscible mixed polyelectrolyte-neutral polymer brush
Journal Article
·
Fri Jul 11 00:00:00 EDT 2014
· Soft Matter
·
OSTI ID:1132100
Acrylic acid polymerization and its graft copolymerization to poly(ethylene oxide) by gamma rays
Thesis/Dissertation
·
Sat Dec 31 23:00:00 EST 1983
·
OSTI ID:6436466