Structural Basis of Cooperative Ligand Binding by the Glycine Riboswitch
Journal Article
·
· Chemistry and Biology
The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 {angstrom} crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.
- Research Organization:
- BROOKHAVEN NATIONAL LABORATORY (BNL)
- Sponsoring Organization:
- USDOE SC OFFICE OF SCIENCE (SC)
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1041815
- Report Number(s):
- BNL--97493-2012-JA
- Journal Information:
- Chemistry and Biology, Journal Name: Chemistry and Biology Journal Issue: 3 Vol. 18; ISSN 1074-5521
- Country of Publication:
- United States
- Language:
- English
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