Enhanced Choice for Viewing Cocaine Pictures in Cocaine Addiction

Journal Article · Sun Feb 01 04:00:00 EST 2009 · Biological Psychiatry

DOI:https://doi.org/10.1016/j.biopsych.2009.02.015· OSTI ID:1040194

Moeller, S J; Goldstein, R; Moeller, S J; Dunning, J P; Alia-Klein, N; Woicik, P A; Hajcak, G; Telang, F; Wang, G -J; Volkow, N D; Goldstein, R Z

Individuals with cocaine use disorder (CUD) chose cocaine over nondrug rewards. In two newly designed laboratory tasks with pictures, we document this modified choice outside of a cocaine administration paradigm. Choice for viewing cocaine, pleasant, unpleasant, or neutral pictures-under explicit contingencies (choice made between two fully visible side-by-side images) and under more implicit contingencies (selections made between pictures hidden under flipped-over cards)-was examined in 20 CUD and 20 matched healthy control subjects. Subjects also provided self-reported ratings of each picture's pleasantness and arousal. Under both contingencies, CUD subjects chose to view more cocaine pictures than control subjects, group differences that were not fully explained by the self-reported picture ratings. Furthermore, whereas CUD subjects choice for viewing cocaine pictures exceeded choice for viewing unpleasant pictures (but did not exceed choice for viewing pleasant pictures, in contrast to their self-reported ratings), healthy control subjects avoided viewing cocaine pictures as frequently as, or even more than, unpleasant pictures. Finally, CUD subjects with the most cocaine viewing selections, even when directly compared with selections of the pleasant pictures, also reported the most frequent recent cocaine use. Enhanced drug-related choice in cocaine addiction can be demonstrated even for nonpharmacologic (pictorial) stimuli. This choice, which is modulated by alternative stimuli, partly transcends self-reports (possibly indicative of a disconnect in cocaine addiction between self-reports and objective behavior) to provide an objective marker of addiction severity. Neuroimaging studies are needed to establish the neural underpinnings of such enhanced cocaine-related choice.

• Research Organization: BROOKHAVEN NATIONAL LABORATORY (BNL)
• Sponsoring Organization: USDOE SC OFFICE OF SCIENCE (SC)
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 1040194
• Report Number(s): BNL--90584-2009-JA; KP1503010
• Journal Information: Biological Psychiatry, Journal Name: Biological Psychiatry Journal Issue: 2 Vol. 66; ISSN BIPCBF; ISSN 0006-3223
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BEHAVIOR
COCAINE
Choice behavior
DRUG ABUSE
IAPS pictures reward
IMAGES
NMR IMAGING
PATIENTS
STIMULI
cocaine addiction
craving
neuropsychology
salience
unconscious motivation