Toward structural elucidation of the gamma-secretase complex
{gamma}-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid {beta}-proteins. As such, this enzyme has emerged as an important target for development of novel therapeutics for Alzheimer disease and cancer. Great progress has been made in the identification and characterization of the membrane complex and its biological functions. One major challenge now is to illuminate the structure of this fascinating and important protease at atomic resolution. Here, we review recent progress on biochemical and biophysical probing of the structure of the four-component complex and discuss obstacles and potential pathways toward elucidating its detailed structure.
- Research Organization:
- BROOKHAVEN NATIONAL LABORATORY (BNL)
- Sponsoring Organization:
- LABORATORY-DIRECTED RESEARCH AND DEVELOPMENT
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1040065
- Report Number(s):
- BNL--90179-2009-JA; YN0100000
- Journal Information:
- Structure, Journal Name: Structure Journal Issue: 3 Vol. 17; ISSN 0969-2126
- Country of Publication:
- United States
- Language:
- English
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