Dual chain synthetic heparin-binding growth factor analogs

Zamora, Paul O; Pena, Louis A; Lin, Xinhua

Title: Dual chain synthetic heparin-binding growth factor analogs

Patent · Tue Apr 24 00:00:00 EDT 2012

OSTI ID:1040008

Zamora, Paul O ^[1]; Pena, Louis A ^[2]; Lin, Xinhua ^[3]

Gaithersburg, MD
Poquott, NY
Plainview, NY

The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-98CH10886

Assignee:: BioSurface Engineering Technologies, Inc. (Rockville, MD)

Patent Number(s):: 8,163,717

Application Number:: 12/574,484

OSTI ID:: 1040008

Country of Publication:: United States

Language:: English

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