The structural basis of transferrin sequestration by transferrin-binding protein B
Journal Article
·
· Nature Structural and Molecular Biology
- Toronto
Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB. Here we present the crystal structures of TbpB from N. meningitidis in its apo form and in complex with human transferrin. The structure reveals how TbpB sequesters and initiates iron release from human transferrin.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- FOREIGN
- OSTI ID:
- 1037480
- Journal Information:
- Nature Structural and Molecular Biology, Vol. 19, Issue 3; ISSN 1545-9993
- Country of Publication:
- United States
- Language:
- ENGLISH
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